sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_8 ;
    pav:version "1.4" .
  sub:_7 prov:value "However, FGFR-1-mediated MAPK activation was not dependent on PKC activation or intracellular calcium, both downstream mediators of PLC-gamma activation. We report that the adaptor protein Shb is also able to bind tyrosine 766 in the FGFR-1, via its SH2 domain, resulting in its subsequent phosphorylation. Overexpression of an SH2 domain mutant Shb caused a dramatic reduction in FGFR-1-mediated FRS2 phosphorylation with concomitant perturbment of the Ras/MEK/MAPK pathway.  -- ( [bcd]  FFT Figure 9.    Shb regulates FGFR-1-mediated FRS2 phosphorylation.  Samples were resolved by SDS-PAGE (10% polyacrylamide), transferred electrophoretically, and blotted with an antiphosphotyrosine antibody (4G10). )" ;
    prov:wasQuotedFrom pubmed:12181353 .
  sub:_8 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12181353 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}