. . . . . . . . . . . . . . . . . . . . . "complex(p(MGI:Fgfr1),p(MGI:Shb)) -> gtp(p(PFM:\"Ras Family\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "However, FGFR-1-mediated MAPK activation was not dependent on PKC activation or intracellular calcium, both downstream mediators of PLC-gamma activation. We report that the adaptor protein Shb is also able to bind tyrosine 766 in the FGFR-1, via its SH2 domain, resulting in its subsequent phosphorylation. Overexpression of an SH2 domain mutant Shb caused a dramatic reduction in FGFR-1-mediated FRS2 phosphorylation with concomitant perturbment of the Ras/MEK/MAPK pathway. -- ( [bcd] FFT Figure 9. Shb regulates FGFR-1-mediated FRS2 phosphorylation. Samples were resolved by SDS-PAGE (10% polyacrylamide), transferred electrophoretically, and blotted with an antiphosphotyrosine antibody (4G10). )" . . "Selventa" . . . . "2014-07-03T14:30:05.052+02:00"^^ . . .