http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#Head http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#assertion http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#provenance http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/Nfkb%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/Nfkb%20Complex http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7797 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_2 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_1 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#assertion http://www.w3.org/2000/01/rdf-schema#label tscript(complex(NCH:"Nfkb Complex")) => r(HGNC:NFKBIA) http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_4 http://www.w3.org/ns/prov#value Cse4p is a variant of histone H3 that has an essential role in chromosome segregation and centromere chromatin structure in budding yeast. Cse4p has a unique 135-amino-acid N terminus and a C-terminal histone-fold domain that is more than 60% identical to histone H3 and the mammalian centromere protein CENP-A. Cse4p and CENP-A have biochemical properties similar to H3 and probably replace H3 in centromere-specific nucleosomes in yeasts and mammals, respectively. In order to identify regions of Cse4p that distinguish it from H3 and confer centromere function, a systematic site-directed mutational analysis was performed. Nested deletions of the Cse4p N terminus showed that this region of the protein contains at least one essential domain. The C-terminal histone-fold domain of Cse4p was analyzed by changing Cse4p amino acids that differ between Cse4p and H3 to the analogous H3 residues. Extensive substitution of contiguous Cse4p residues with H3 counterparts resulted in cell lethality. However, all large lethal substitution alleles could be subdivided into smaller viable alleles, many of which caused elevated rates of mitotic chromosome loss. The results indicate that residues critical for wild-type Cse4p function and high-fidelity chromosome transmission are distributed across the entire histone-fold domain. Our findings are discussed in the context of the known structure of H3 within the nucleosome and compared with previous results reported for CENP-A. http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10454560 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10454560 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#_4 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM http://purl.org/dc/terms/created 2014-07-03T14:29:48.168+02:00 http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAtiuY6-8mgUZ_5Qwo-z3WBpiw6shF2ykY5d_BN2dlNlM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234