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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#_7 http://www.w3.org/ns/prov#value BRCA1, a breast and ovarian tumor suppressor, is a phosphoprotein whose cellular expression level is regulated in a cell cycle-dependent manner. BRCA1 interacts with BARD1 to generate significant ubiquitin ligase activity which catalyzes nontraditional Lys-6-linked polyubiquitin chains. However, it is not clear how the activity is regulated and how this affects BRCA1's multiple cellular functions. Here we show that the ubiquitin ligase activity of BRCA1-BARD1 is down-regulated by CDK2. http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15665273 http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15665273 http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#_7 http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos http://purl.org/dc/terms/created 2014-07-03T14:30:31.010+02:00 http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAtp1C29LmTUqoDJYcJaIZTBGYIvahGk0raEpoMx9oLos http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234