@prefix dct: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAtvK2M8Frine6n-ace8LX-sB9PdGJsBAF9kd6S5oU05g> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAtvK2M8Frine6n-ace8LX-sB9PdGJsBAF9kd6S5oU05g#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 geneProductOf: hgnc:11270 ;
    a Protein: .
  sub:_2 hasAgent: sub:_3 ;
    a go:0003824 .
  sub:_3 geneProductOf: hgnc:286 ;
    a Protein: .
  sub:_4 hasAgent: sub:_5 ;
    a go:0016301 .
  sub:_5 geneProductOf: hgnc:6871 ;
    a Protein: .
  sub:_6 rdf:object sub:_4 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_2 ;
    a rdf:Statement .
  sub:_7 occursIn: atcc:CRL-1573.aspx , species:9606 ;
    rdf:object sub:_6 ;
    rdf:predicate belv:decreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "cat(p(HGNC:ADRB2)) -> kin(p(HGNC:MAPK1))" , "p(HGNC:SPRY2) -| (cat(p(HGNC:ADRB2)) -> kin(p(HGNC:MAPK1)))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_9 ;
    pav:version "1.4" .
  sub:_8 prov:value "To address this, 293T cells were transfected with constructs for beta2AR, HA-tagged hSpry2, and FLAG-tagged ERK2....The data shown in Fig. 5 demonstrate that ERK2 phosphorylation was elevated 5 min after isoprenaline addition and that this level was sustained for the next 25 min at least. hSpry2 substantially inhibited ERK2 phosphorylation to the degree that any level of phosphorylation in the data shown was only evident at 5 min." ;
    prov:wasQuotedFrom pubmed:11698404 .
  sub:_9 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11698404 ;
    prov:wasDerivedFrom beldoc: , sub:_8 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:29:58.998+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}