http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#Head http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#assertion http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#provenance http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#assertion http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D004730 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D042783 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.ebi.ac.uk/chebi/searchId.do?chebiId=26523 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=25461 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:myxothiazol) -| a(CHEBI:"reactive oxygen species") http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_2 http://www.w3.org/ns/prov#value Because reactive oxygen species (ROS) generated from mitochondria are one of the signaling molecules induced by hypoxia, the role of ROS in hypoxia-induced TLR4 down-regulation was evaluated. Our data showed that hypoxia increased ROS generation and that hypoxia-induced TLR4 down-regulation was inhibited by myxothiazol, a mitochondrial site III electron transport inhibitor. Hypoxia also inhibited AP-1 translocation. Since the TLR4 promoter has a binding site for AP-1, hypoxia-induced TLR4 down-regulation may be due to an ROS-mediated decrease in AP-1-binding activity. http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12165534 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12165534 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#_2 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo http://purl.org/dc/terms/created 2014-07-03T14:30:04.933+02:00 http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAtxt-5q6O5y2Vwgoc4YaN3WqrmAE_IGeG7F90wsTFGTo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234