sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "1.4" .
  sub:_6 prov:value "UCP-1 expression is under complex regulation; an enhancer element in the 5'flanking region of the ucp-1 gene has been described with putative binding sites for the thyroid hormone receptor, retinoic acid receptors and PPARs, as recently reviewed (Rousset et al. 2004). PPARc is a nuclear receptor essential for adipogenic differentiation in both WAT and BAT (Lowell 1999), that also displays a thermogenic function upon activation, with prostaglandings being the physiological ligands and TZD pharmacological activators (Rosen & Spiegelman 2001). Although b-adrenergic stimulation is the main physiological pathway that induces thermogenesis and UCP-1 expression in BAT, it is likely to be mediated by the induction of the PPARc coactivator (PGC-1), a master coactivator that binds PPARc, PPARa, thyroid hormone receptor and retinoic acid receptors (Puigserver & Spiegelman 2003)." ;
    prov:wasQuotedFrom pubmed:15777261 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15777261 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}