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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#_5 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#_4 http://www.w3.org/ns/prov#value In Rat1, NIH 3T3, and HEK293 cells, increases in the intracellular levels of cAMP stimulate phosphorylation of GSK-3α and -β, as demonstrated by immunoblotting with GSK-3 phosphorylation-specific antibodies. As shown in Fig. 1, the cell-permeable cAMP analogue 8-Br-cAMP induced a marked increase in phosphorylation of GSK-3α and - β at serine 21 and 9, respectively, whereas the structurally related cGMP analogue 8-Br-cGMP had little effect. Forskolin, which activates adenyl cyclase thus raising intracellular cAMP levels (15), triggered a similar elevation in GSK-3 phosphorylation at serine 21 and 9. In Rat1 cells, isoproterenol, which activates the b-adrenergic receptor stimulating adenylate cyclase and increasing endogenous cAMP levels (16, 17), also efficiently stimulated GSK-3 phosphorylation at these serine sites. In NIH 3T3 cells that contain few of the β-adrenergic receptors, stimulation with other G-protein-coupled receptor agonists, such as lysophosphatidic acid. also led to GSK-3 phosphorylation (data not shown) http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11035810 http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#_5 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11035810 http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#_4 http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg http://purl.org/dc/terms/created 2014-07-03T14:29:34.648+02:00 http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAub2JLbhxkKq69C46ZHS1W5bU_zKT5_6X7sMRUJCPllg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234