http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#Head http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#assertion http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#provenance http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#assertion http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_1 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2363 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_3 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_3 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/MAPK%20Erk1%2F3%20Family http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_2 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_1 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:CRKL,pmod(P,Y)) -> kin(p(PFH:"MAPK Erk1/3 Family")) http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_5 http://www.w3.org/ns/prov#value Overexpression of Lyn induced constitutive phosphorylation of CrkL and activation of Erk, whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo-induced phosphorylation of CrkL and activation of Erk. Furthermore, Lyn, but not Jak2, phosphorylated CrkL on tyrosine in in vitro kinase assays. Together, the present study suggests that, upon Epo stimulation, CrkL is recruited to the EpoR through interaction between the CrkL SH2 domain and phosphorylated Tyr(460) in the EpoR cytoplasmic domain and undergoes tyrosine phosphorylation by receptor-associated Lyn to activate the downstream signaling pathway leading to the activation of Erk and Elk-1. http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11443118 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11443118 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#_5 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI http://purl.org/dc/terms/created 2014-07-03T14:29:57.185+02:00 http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAucOYnZCX6zWT0qM7m-wjGNRl--5ADkj8uJ8k8ohKlWI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234