http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#Head http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#assertion http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#provenance http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/AP-1%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/AP-1%20Complex http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_1 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0034976 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"response to endoplasmic reticulum stress") -> tscript(complex(NCM:"AP-1 Complex")) http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_3 http://www.w3.org/ns/prov#value ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecular chaperones. Upon ER stress, ATF6 translocates from the ER to the Golgi where it is processed to its active form. We have found that the ER chaperone BiP/GRP78 binds ATF6 and dissociates in response to ER stress. Loss of BiP binding correlates with the translocation of ATF6 to the Golgi, which was slowed in cells overexpressing BiP. Two Golgi localization signals (GLSs) were identified in ATF6. Removal of BiP binding sites from ATF6, while retaining a GLS, resulted in its constitutive translocation to the Golgi. These results suggest that BiP retains ATF6 in the ER by inhibiting its GLSs and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi. http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12110171 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12110171 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#_3 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU http://purl.org/dc/terms/created 2014-07-03T14:30:04.369+02:00 http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAufnOmmE8YNFZses5dIHO3hcW9wQLo4NbdJ1-ePa1rPU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234