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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#_3 http://www.w3.org/ns/prov#value The concentration of GSH in the lung tissue of CFTR-KO mice, however, was not significantly different from that in WT mice. The activities of glutathione reductase and glutathione peroxidase in the lung tissue of CFTR-KO mice were significantly increased compared with those in WT mice (48 and 28%, respectively). Tissue lipid and DNA oxidation were evaluated by measurement of thiobarbituric acid-reactive substances and 8-hydroxy-2'-deoxyguanosine, respectively. The levels of thiobarbituric acid-reactive substances and 8-hydroxy-2'-deoxyguanosine in the lung tissue of CFTR-KO mice were significantly increased compared with those in WT mice. These data support our hypothesis that a mutation in the CFTR gene can affect the antioxidant defenses in the lung and may contribute to the exaggerated inflammatory response observed in CF. http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11404242 http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11404242 http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#_3 http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s http://purl.org/dc/terms/created 2014-07-03T14:29:56.568+02:00 http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAurKJCLilBj6S64P5-6C98TX1E86GFjacgzcpOx_Wt6s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234