sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "1.4" .
  sub:_3 prov:value "ALA synthase and GLUT4 have short half-lives and increase rapidly in skeletal muscle in response to exercise (17, 36). The concentrations of ALA synthase and GLUT4 after 5 days of exercise probably represent their new steady-state concentration, as there was no significant difference between their concentrations after 3 days (data not shown) and after 5 days of exercise. Cytochrome c and citrate synthase appear to have half-lives in the range of 6-8 days, and they increase with a half-time of 7 days in response to a constant daily exercise stimulus (9). There is no previous information regarding the time course of the adaptive increase in muscle cytochrome oxidase subunit I to exercise; however, it appears from the present results to increase at least as rapidly as citrate synthase and cytochrome c. The magnitude of this adaptive response is similar to that induced by 6 days of a treadmill running program used in earlier studies (36). PGC-1 Gene transcription in skeletal muscle increases rapidly after a bout of exercise The level of PGC-1 mRNA was determined by Northern blot using a full-length PGC-1 probe. PGC-1 from triceps muscles of sedentary rats migrates as a single band on a 1% agarose gel (above the 28S rRNA band) (Fig. 2). There was a twofold increase in the fulllength PGC-1 mRNA evident in muscles taken 6 h after exercise (Fig. 2)." ;
    prov:wasQuotedFrom pubmed:12468452 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12468452 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}