sub:provenance { sub:assertiondcterms:description "[Direct correlations of blood ethanol and acetaldehyde concentrations, cardiovascular haemodynamic responses, and the subjective perceptions after challenge with low (0.2g/kg) to moderate (0.5g/kg) alcohol in individuals with different ALDH2 genotypes support the notion that full protection against alcoholism byALDH2*2/*2 may derive from either abstinence or deliberate moderation in alcohol consumption due to strong discomfort from physiological and psychological responses caused by persistently elevated blood acetaldehyde after ingestion of a small amount of alcohol, and that the partial protection by ALDH2*1/*2 can be ascribed to significantly lower acetaldehyde build-up in blood and the according adverse reactions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ; wi:evidencedgn-void:source_evidence_curated ; sio:SIO_000772miriam-pubmed:17590986 ; prov:wasDerivedFromdgn-void:CTD_human ; prov:wasGeneratedByeco:ECO_0000218 . dgn-void:CTD_humanpav:importedOn "2017-01-25"^^xsd:date . dgn-void:source_evidence_curatedaeco:ECO_0000205 ; rdfs:comment "Gene-disease associations manually curated."@en ; rdfs:label "DisGeNET evidence - CURATED"@en . }