[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_1", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://amigo.geneontology.org/amigo/term/GO:0008286" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/decreases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=26523" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "a(CHEBI:\"reactive oxygen species\") -| bp(GO:\"insulin receptor signaling pathway\")" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_3" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_2", "http://www.w3.org/ns/prov#value" : [ { "@value" : "Two-hour exposure to approximately 25 microM H2O2 (generated by adding glucose oxidase to the medium) resulted in disruption of the normal insulin stimulated insulin receptor substrate (IRS)-1 and phosphatidylinositol (PI) 3-kinase cellular redistribution between the cytosol and an internal membrane pool (low density microsomal fraction (LDM)). This was associated with reduced insulin-stimulated IRS-1 and p85-associated PI 3-kinase activities in the LDM (84 and 96% inhibition, respectively). The effect of this finding on the downstream insulin signal was demonstrated by a 90% reduction in insulin stimulated protein kinase B (PKB) serine 473 phosphorylation and impaired activation of PKBalpha and PKBgamma." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/10187855" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_3", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/10187855" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_2" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:29:46.418+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#pubinfo" } ]