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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_2 http://www.w3.org/ns/prov#value Two-hour exposure to approximately 25 microM H2O2 (generated by adding glucose oxidase to the medium) resulted in disruption of the normal insulin stimulated insulin receptor substrate (IRS)-1 and phosphatidylinositol (PI) 3-kinase cellular redistribution between the cytosol and an internal membrane pool (low density microsomal fraction (LDM)). This was associated with reduced insulin-stimulated IRS-1 and p85-associated PI 3-kinase activities in the LDM (84 and 96% inhibition, respectively). The effect of this finding on the downstream insulin signal was demonstrated by a 90% reduction in insulin stimulated protein kinase B (PKB) serine 473 phosphorylation and impaired activation of PKBalpha and PKBgamma. http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10187855 http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10187855 http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#_2 http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE http://purl.org/dc/terms/created 2014-07-03T14:29:46.418+02:00 http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAv_o9UzAonUOeKn0ygCPHKh0uOPo9JnfONNC1tUT3wGE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234