sub:provenance {
  sub:assertion dcterms:description "[In this study, we further characterize the interactions between Hb and A? in vitro and in vivo and report the following observations: 1) the binding of Hb to A? required iron-containing heme; 2) other heme-containing proteins, such as myoglobin and cytochrome C, also bound to A?; 3) hemin-induced cytotoxicity was reduced in neuroblastoma cells by low levels of A?; 4) Hb was detected in neurons and glial cells of post-mortem AD brains and was up-regulated in aging and APP/PS1 transgenic mice; 5) microinjection of human Hb into the dorsal hippocampi of the APP/PS1 transgenic mice induced the formation of an envelope-like structure composed of A? surrounding the Hb droplets.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ;
    wi:evidence dgn-void:source_evidence_literature ;
    sio:SIO_000772 miriam-pubmed:22412990 ;
    prov:wasDerivedFrom dgn-void:BEFREE ;
    prov:wasGeneratedBy eco:ECO_0000203 .
  dgn-void:BEFREE pav:importedOn "2017-02-19"^^xsd:date .
  dgn-void:source_evidence_literature a eco:ECO_0000212 ;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en ;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}