. . . . . . . . . . . . . "p(HGNC:SP1) -> p(HGNC:VEGFA)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "IGF-1 receptor signaling when blocked with anti IGF-1R alpha neutralizing antibody, and when, either the 2.6 kb or the 0.35 kb VPF/VEGF reporter construct was transfected into AsPC-1 cells. The reporter activity of the 2.6 kb VPF/VEGF promoter showed a 50% decrease, and the 0.35kb VPF/VEGF promoter (mainly Sp1 binding sites) showed a 40% decrease compared with that of the IgG control. These results suggested that in AsPC-1 cells, the IGF-1 receptor signaling promotes VPF/VEGF expression mainly through transcriptional regulation, where the transcription factor Sp1 plays an important role." . . "Selventa" . . . . "2014-07-03T14:30:18.224+02:00"^^ . . .