@prefix this: <
http://www.tkuhn.ch/bel2nanopub/RAvcRpzUyQsjzJkWszBD8h86c4E_H5oaK1kuAs8_bfYfw
> .
@prefix sub: <
http://www.tkuhn.ch/bel2nanopub/RAvcRpzUyQsjzJkWszBD8h86c4E_H5oaK1kuAs8_bfYfw#
> .
@prefix beldoc: <
http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix dct: <
http://purl.org/dc/terms/
> .
@prefix dce: <
http://purl.org/dc/elements/1.1/
> .
@prefix pav: <
http://purl.org/pav/
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix belv: <
http://www.selventa.com/vocabulary/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix schem: <
http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/
> .
@prefix go: <
http://amigo.geneontology.org/amigo/term/GO:
> .
@prefix Protein: <
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080
> .
@prefix hgnc: <
http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=
> .
@prefix geneProductOf: <
http://purl.obolibrary.org/obo/RO_0002204
> .
@prefix hasAgent: <
http://semanticscience.org/resource/SIO_000139
> .
@prefix atcc: <
http://www.lgcstandards-atcc.org/Products/All/
> .
@prefix occursIn: <
http://purl.obolibrary.org/obo/BFO_0000066
> .
@prefix species: <
http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=
> .
@prefix pubmed: <
http://www.ncbi.nlm.nih.gov/pubmed/
> .
@prefix orcid: <
http://orcid.org/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
sub:_1
hasAgent:
sub:_2
;
a
go:0003824
.
sub:_2
geneProductOf:
hgnc:3594
;
a
Protein:
.
sub:_3
occursIn:
atcc:HTB-22.aspx
,
species:9606
;
rdf:object
sub:_1
;
rdf:predicate
belv:decreases
;
rdf:subject
schem:C75
;
a
rdf:Statement
.
sub:assertion
rdfs:label
"a(SCHEM:C75) -| cat(p(HGNC:FASN))" .
}
sub:provenance
{
beldoc:
dce:description
"Approximately 61,000 statements." ;
dce:rights
"Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title
"BEL Framework Large Corpus Document" ;
pav:authoredBy
sub:_5
;
pav:version
"1.4" .
sub:_4
prov:value
"MCF-7 breast cancer cells were selected for study because they have an intact TP53 pathway and undergo little apoptosis following FAS blockade. Two chemically distinct inhibitors of FAS (the natural mycotoxin cerulenin and the novel small-molecule inhibitor C75) were studied in parallel to provide a broad picture of consequences suffered by the loss of FAS function on TP53 signaling. Treatment with either cerulenin or C75 induced TP53 protein accumulation at 24 h in MCF-7 cells." ;
prov:wasQuotedFrom
pubmed:15583825
.
sub:_5
rdfs:label
"Selventa" .
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prov:hadPrimarySource
pubmed:15583825
;
prov:wasDerivedFrom
beldoc:
,
sub:_4
.
}
sub:pubinfo
{
this:
dct:created
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xsd:dateTime
;
pav:createdBy
orcid:0000-0001-6818-334X
,
orcid:0000-0002-1267-0234
.
}