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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#_7 http://www.w3.org/ns/prov#value Carson et al. (1995) concluded that SRE1 is a hypertrophy regulatory element that activates specific contractile protein genes to produce more mRNA in response to overload conditions. Serum response factor (SRF) is a transcription factor that homodimerizes to SRE1 on the skeletal alpha-actin gene (Lee et al. 1992). Increases in the quantity (Carson et al. 1995), and potentially the post-translational status (Fluck et al. 1999), of SRF were noted in hypertrophying muscles. An increase in SRF transcriptional activity should enhance transcription of skeletal alpha-actin mRNA. Therefore, it is likely that during the late phases of a hypertrophic stimulus, transcription of the alpha-actin gene is an important contributor to muscle hypertrophy. http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12205177 http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12205177 http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#_7 http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4 http://purl.org/dc/terms/created 2014-07-03T14:30:05.385+02:00 http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAvdq8yLRIb3Ob_YEH20xfGND8JMpS7acfgdhLlOY2zM4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234