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[Plasma-cell derived Ig genes (light- and heavy-chain pairs, n?=?4; heavy chains, n?=?33) resembled mutation patterns seen in other autoimmune diseases, predominantly displaying selection against replacement mutations within the framework region of Ig genes (10 of 15), which is responsible for structural integrity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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