. . . . . . . . . . . . . . . . . . . "complex(a(SCHEM:\"Heregulin beta1\"),p(HGNC:ERBB2)) -> kin(p(HGNC:EGFR))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "studies of MCF-7 breast cancer cells stimulated with heregulin showed increased HIF-1a protein synthesis that was inhibited by treatment with rapamycin a macrolide antibiotic that inhibits mammalian target of rapamycin (mTOR; a kinase that functions downstream of PI3K and AKT). The effect of heregulin was mediated via the 5-untranslated region of HIF-1a mRNA47. The known targets for phosphorylation by mTOR are regulators of protein synthesis (FIG. 1)." . . "Selventa" . . . . "2014-07-03T14:30:16.675+02:00"^^ . . .