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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#_7 http://www.w3.org/ns/prov#value Recently, we and others have identified an ubiquitin E3 ligase, the SCF(SKP2) complex, that mediates p27 ubiquitin-dependent proteolysis [5-7]. Here we report that PTEN and the PI 3-kinase pathway regulate p27 protein stability.We found that ectopic expression of SKP2 alone is sufficient to reverse PTEN-induced p27 accumulation, restore the kinase activity of cyclin E/CDK2, and partially overcome the PTEN-induced G1 cell cycle arrest. http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11250155 http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11250155 http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#_7 http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY http://purl.org/dc/terms/created 2014-07-03T14:29:54.632+02:00 http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAvvnc8CbPibsju5-07eovT10Y5Cw2M0FVPHXlGQzkfwY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234