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[By analogy with experimental works on alpha1b adrenergic receptor, showing that mutations could result in constitutive activation of the receptor, it was hypothezised, that similar but spontaneous somatic mutations of the Thyrotropin-receptor could be the cause of thyroid toxic adenomas.This hypothesis has been confirmed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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