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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#_4 http://www.w3.org/ns/prov#value Stimulation of phosphoinositide-hydrolysing phospholipase C (PLC) generating inositol-1,4,5-trisphosphate is a major calcium signalling pathway used by a wide variety of membrane receptors, activating distinct PLC-beta or PLC-gamma isoforms. Here we report a new PLC and calcium signalling pathway that is triggered by cyclic AMP (cAMP) and mediated by a small GTPase of the Rap family. Activation of the adenylyl cyclase-coupled beta2-adrenoceptor expressed in HEK-293 cells or the endogenous receptor for prostaglandin E1 in N1E-115 neuroblastoma cells induced calcium mobilization and PLC stimulation, seemingly caused by cAMP formation, but was independent of protein kinase A (PKA). We provide evidence that these receptor responses are mediated by a Rap GTPase, specifically Rap2B, activated by a guanine-nucleotide-exchange factor (Epac) regulated by cAMP, and involve the recently identified PLC-epsilon isoform. http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11715024 http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11715024 http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#_4 http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E#pubinfo http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E http://purl.org/dc/terms/created 2014-07-03T14:29:59.271+02:00 http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAwbiwdFSOshjU9K4Qb_6drVGv96X_GjqLWf2hJ07nE8E http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234