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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#_2 http://www.w3.org/ns/prov#value when administered intravenously, PAF is hypotensive in all species studied In animal species such as the rat, where platelets are insensitive to PAF action, no tachyphylaxis was observed action of PAF on the heart, peripheral vasculature, and microcirculation may account, at least in part, for the reduction of systemic blood pressure. PAF decreases the cardiac output through several mechanisms: 1) it reduces venous blood return as the consequence of peripheral vasodilatation or vasoconstriction and increased microvascular permeability; 2) it produces a right ventricular overload with an increased right atrial pressure and a reduced filling of left ventricle as the result of an increase in pulmonary vascular resistance; 3) it may impair cardiac function by a direct negative inotropic effect and by reduction of coronary blood flow (CBF); and 4) finally, PAF was shown to affect cardiac electrical activity and the conducting system. 3) it may impair cardiac function by a direct negative inotropic effect and by reduction of coronary blood flow (CBF); and 4) finally, PAF was shown to affect cardiac electrical activity and the conducting system. High doses of PAF, in contrast, produced a sustained decrease of cardiac index, tachycardic response, and transient fall followed by sustained increase of total peripheral resistances In the mesenteric district, a marked reduction of blood flow consequent to the increase in mesenteric resistance was observed (380). it was found that delayed and persistent but not early hypotension induced by PAF is inhibited by Nv-nitro-L-arginine, which inhibits the production of nitric oxide from endothelial cells, thus suggesting a role for the endothelium derived relaxing factor(406). http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11015622 http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11015622 http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#_2 http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg http://purl.org/dc/terms/created 2014-07-03T14:29:52.547+02:00 http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAxWVJKw9Ljb34VrrYOp70RMEz6ehukDnISRGGdvU0Pjg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234