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http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/PD%2098%2C059 http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#_6 http://purl.org/dc/terms/subject TextLocation http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#value Abstract http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"PD 98,059") -| (composite(p(MGI:Ifng),a(SCHEM:Lipopolysaccharide)) -> p(MGI:Nos2)) http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#assertion http://www.w3.org/2000/01/rdf-schema#label composite(p(MGI:Ifng),a(SCHEM:Lipopolysaccharide)) -> p(MGI:Nos2) http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#provenance http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 2000 hand curated statements drawn from 57 PubMeds. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#_8 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAyOfYoNTn_LYVZ2rJQIKMCv6qjDf8fs8t-9Er8CWGTY4#_7 http://www.w3.org/ns/prov#value Further, LPS + IFNγ -induced expression of iNOS and Nox1 was attenuated by the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor PD98059, the JNK inhibitor SP600125, the Jak2 inhibitor AG490 and the NFκB inhibitor MG132, but not by the p38 mitogen-activated protein kinase inhibitor SB203580. LPS + IFNγ stimulated phosphorylation of ERK, JNK and Jak2, and degradation of IκB, but only Jak2 phosphorylation was sensitive to tripterine (50-200 nM). 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