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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#_5 http://www.w3.org/ns/prov#value The main downstream targets (of BRCA1) identified so far are p53-responsive genes, including p21 and BcIX13. BRCA1 binds to BRCA2, p53, RAD51 and many other proteins involved in cell cycling and DNA-damage response14,15 (Fig. 2a). The involvement of BRCA1 in response to DNA damage is supported by extensive data, including evidence that BRCA1 is phosphorylated by the ataxia telangiectasia mutated (ATM) and checkpoint kinase 2 (CHK2) proteins in response to DNA damage16,17, that cells without functional BRCA1 do not arrest in G2 after DNA damage and are deficient in transcription-coupled repair18,19, and that BRCA1 is part of the RAD50-MRE11-p95 complex, an essential component of recombination- mediated repair of DNA double-stranded breaks20. http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11329055 http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11329055 http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#_5 http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY http://purl.org/dc/terms/created 2014-07-03T14:29:55.937+02:00 http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAyVTQqBLj9CRmvqdtMZ8Y2Rg6SPtMDIrq0tlze9nN6uY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234