@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAybSKc4mks8eLPD7A8YCZ5QUuXLt0wr0-pSVKKvlyjjA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAybSKc4mks8eLPD7A8YCZ5QUuXLt0wr0-pSVKKvlyjjA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:8822;
    a Protein: .
  
  sub:_2 geneProductOf: hgnc:11920;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0003824 .
  
  sub:_4 geneProductOf: hgnc:270;
    a Protein: .
  
  sub:_5 rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_2;
    a rdf:Statement .
  
  sub:_6 occursIn: atcc:CCL-2.aspx, species:9606;
    rdf:object sub:_5;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:FAS) -> cat(p(HGNC:PARP1))", "p(HGNC:PEA15) -| (p(HGNC:FAS) -> cat(p(HGNC:PARP1)))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_8;
    pav:version "1.4" .
  
  sub:_7 prov:value "Next, we sought to analyse whether the decrease in FADD-FLICE association caused by PED overexpression affected FLICE protease activity. To this end, we incubated identical amounts of in vitro translated 35S-PARP, a death substrate cleaved by the active FLICE, with extracts from control or PED-overexpressing cells stimulated with IgMFAS. A major band, corresponding to the 26 kDa cleavage product of 35S-PARP was identified after incubation with extracts from IgMFAS-stimulated control cells (Figure 8). The intensity of the band was fivefold lower after PARP incubation with extracts from FAS-unstimulated cells. Most important, in this assay, PARP cleavage was threefold less effective in PED overexpressing than in control cells. No 26 kDa band was detectable in the absence of cell extract addition. Thus, cleavage of death substrates by active FLICE occurs less efficiently in cells overexpressing PED.";
    prov:wasQuotedFrom pubmed:10442631 .
  
  sub:_8 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:10442631;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:47.998+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}