[ {
  "@graph" : [ {
    "@id" : "http://rdf.disgenet.org/resource/gda/DGN69a83212cbd939fc28a2ac504c75fb77",
    "@type" : [ "http://semanticscience.org/resource/SIO_001123" ],
    "http://semanticscience.org/resource/SIO_000628" : [ {
      "@id" : "http://identifiers.org/ncbigene/4217"
    }, {
      "@id" : "http://linkedlifedata.com/resource/umls/id/C3887505"
    } ]
  } ],
  "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#publicationInfo"
    } ]
  } ],
  "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#head"
}, {
  "@graph" : [ {
    "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#assertion",
    "http://purl.org/dc/terms/description" : [ {
      "@language" : "en",
      "@value" : "[We found (a) abundant tissue TNF-alpha and ASK1 expression throughout all layers of the intestine in neonates with NEC, suggesting that TNF-alpha/ASK1 may be a potential source (indicators) of intestinal injury in neonates with NEC; (b) TNF-alpha-induced rapid and transient activation of JNK/p38 apoptotic signaling in all cell lines suggests that this may be an important molecular characteristic of NEC; (c) TNF-alpha-induced rapid and transient ROS production in RIE-1 cells indicates that mitochondria are the predominant source of ROS, demonstrated by significantly attenuated response in mitochondrial DNA-depleted (RIE-1-rho) intestinal epithelial cells; (d) further studies with mitochondria-targeted antioxidant PBN supported our hypothesis that effective mitochondrial ROS trapping is protective against TNF-alpha/ROS-induced intestinal epithelial cell injury; (e) TNF-alpha induces significant mitochondrial dysfunction in intestinal epithelial cells, resulting in increased production of mtROS, drop in mitochondrial membrane potential (MMP) and decreased oxygen consumption; (f) although the significance of mitochondrial autophagy in NEC has not been unequivocally shown, our studies provide a strong preliminary indication that TNF-alpha/ROS-induced mitochondrial autophagy may play a role in NEC, and this process is a late phenomenon.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."
    } ],
    "http://purl.org/ontology/wi/core#evidence" : [ {
      "@id" : "http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature"
    } ],
    "http://semanticscience.org/resource/SIO_000772" : [ {
      "@id" : "http://identifiers.org/pubmed/20716917"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://rdf.disgenet.org/v5.0.0/void/BEFREE"
    } ],
    "http://www.w3.org/ns/prov#wasGeneratedBy" : [ {
      "@id" : "http://purl.obolibrary.org/obo/ECO_0000203"
    } ]
  }, {
    "@id" : "http://rdf.disgenet.org/v5.0.0/void/BEFREE",
    "http://purl.org/pav/importedOn" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#date",
      "@value" : "2017-02-19"
    } ]
  }, {
    "@id" : "http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature",
    "@type" : [ "http://purl.obolibrary.org/obo/ECO_0000212" ],
    "http://www.w3.org/2000/01/rdf-schema#comment" : [ {
      "@language" : "en",
      "@value" : "Gene-disease associations inferred from text-mining the literature."
    } ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@language" : "en",
      "@value" : "DisGeNET evidence - LITERATURE"
    } ]
  } ],
  "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2017-10-17T13:14:30+02:00"
    } ],
    "http://purl.org/dc/terms/rights" : [ {
      "@id" : "http://opendatacommons.org/licenses/odbl/1.0/"
    } ],
    "http://purl.org/dc/terms/rightsHolder" : [ {
      "@id" : "http://rdf.disgenet.org/v5.0.0/void/IBIGroup"
    } ],
    "http://purl.org/dc/terms/subject" : [ {
      "@id" : "http://semanticscience.org/resource/SIO_000983"
    } ],
    "http://purl.org/net/provenance/ns#usedData" : [ {
      "@id" : "http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf"
    } ],
    "http://purl.org/pav/authoredBy" : [ {
      "@id" : "http://orcid.org/0000-0001-5999-6269"
    }, {
      "@id" : "http://orcid.org/0000-0002-7534-7661"
    }, {
      "@id" : "http://orcid.org/0000-0002-9383-528X"
    }, {
      "@id" : "http://orcid.org/0000-0003-0169-8159"
    }, {
      "@id" : "http://orcid.org/0000-0003-1244-7654"
    } ],
    "http://purl.org/pav/createdBy" : [ {
      "@id" : "http://orcid.org/0000-0003-0169-8159"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "v5.0.0.0"
    } ]
  }, {
    "@id" : "http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf",
    "http://purl.org/pav/version" : [ {
      "@value" : "v5.0.0"
    } ]
  } ],
  "@id" : "http://rdf.disgenet.org/resource/nanopub/NP678859.RAycX-r3WJEbIt0bSnxon6Tur50C82RRps_4gDHuLVBMs#publicationInfo"
} ]