http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#Head http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#assertion http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#provenance http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#assertion http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_2 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6871 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_4 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0005525 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4387 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_3 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_1 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:MAPK1)) -> gtp(p(HGNC:GNAI3)) http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_6 http://www.w3.org/ns/prov#value # Ariadne: An in vitro phosphorylation assay demonstrates that Erk2-dependent phosphorylation of GAIP stimulates its GTPase-activating protein activity toward the Galpha i3 protein ( k = 0.187 .. 0.001 s -1 , EC 50 = 1.12 .. 0.10 .. M ) when compared with unphosphorylated recombinant GAIP ( k = 0.145 .. 0.003 s -1 , EC 50 = 3.16 .. 0.12 .. M ) or to GAIP phosphorylated by other Ser/Thr protein kinases (protein kinase C, casein kinase II). [Regulation] # Ariadne: Using a panel of Ser/Thr protein kinases in an in vitro assay, we demonstrate that the phosphorylation of GAIP by a recombinant Erk2 stimulated its GAP activity toward the Galpha i3 protein when compared with the activity of unphosphorylated GAIP . [Regulation] http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10993892 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10993892 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#_6 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA http://purl.org/dc/terms/created 2014-07-03T14:29:52.407+02:00 http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAz2kMjYyCiQE093LVUaRNMrh8L3-hLA0YewoxGPZm-OA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234