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http://purl.obolibrary.org/obo/RO_0002204
http://www.informatics.jax.org/marker/MGI:95294
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http://amigo.geneontology.org/amigo/term/GO:0016301
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tloc(p(MGI:Egfr),GOCCACC:"GO:0005886",GOCCACC:"GO:0005768") =| kin(p(MGI:Egfr))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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1.4
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Epidermal growth factor (EGF) binding to its receptor causes rapid phosphorylation of the clathrin heavy chain at tyrosine 1477, which lies in a domain controlling clathrin assembly. EGF-mediated clathrin phosphorylation is followed by clathrin redistribution to the cell periphery and is the product of downstream activation of SRC kinase by EGF receptor (EGFR) signaling. In cells lacking SRC kinase, or cells treated with a specific SRC family kinase inhibitor, EGF stimulation of clathrin phosphorylation and redistribution does not occur, and EGF endocytosis is delayed.
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Selventa
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2014-07-03T14:29:46.310+02:00
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