sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_9 ;
    pav:version "1.6" .
  sub:_8 prov:value """Preformed Mac-1 is stored in granules in neutrophils and can be rapidly mobilized
to the neutrophil surface after exposure to degranulation stimuli such as the bacterial
peptide fMLP or to cytokines (Altieri and Edgington, 1988). However, it
is not yet competent for ligand binding. The ligand binding site lies on an extracellular
region of the α subunit called the I domain, that is inaccessible to
potential ligands unless integrins are activated. Integrin activation involves a
conformational change such that the I domain is exposed (Oxvig et al., 1999). This
change may be induced by phosphorylation of the cytoplasmic tail of the β subunit
(Buyon et al., 1997), possibly through a pathway involving the small GTP-binding
protein Rho, but this is still unclear.""" ;
    prov:wasQuotedFrom pubmed:12891700 .
  sub:_9 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12891700 ;
    prov:wasDerivedFrom beldoc: , sub:_8 .
}