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[Presenilin 1 (PS1), a causative molecule of familial Alzheimer's disease (AD), is known to be an unprimed substrate of glycogen synthase kinase 3 ? (GSK3?) [Twomey and McCarthy (2006) FEBS Lett 580:4015-4020] and is phosphorylated at serine 353, 357 residues in its cytoplasmic loop region [Kirschenbaum et al.(2001) J Biol Chem 276:7366-7375].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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