[We speculated that protein kinase C isoforms up-regulated by 4-hydroxynonenal that was detoxified by ALDH2 and ADH2 may account for the long-term development of diabetic nephropathy and severe retinopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

Gene-disease associations inferred from text-mining the literature.
DisGeNET evidence - LITERATURE

[We present an investigation of joint genetic and clinical factors associated with atherosclerosis that shows predictive results for both cases, as well as enhanced performance for their combination.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Differences at the genetic level revealed distinct disease functions and operational pathways in African Americans and Caucasians in spontaneous preterm birth.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Additionally, we report results on associations of variants in ADH1B and ADH1C with ischemic heart disease and stroke in the context of a meta-analysis of previously published prospective studies published up to November 2011.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No adverse effects of ALDH2 or ADH1B alone were observed with mental disorder risks.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as indicator of mental disorders in Japanese employees.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American college students.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Likewise, the proportion of persons with positive results for ethanol-induced cutaneous erythema differed significantly depending on the ADH2 genotype in both the ALDH2(1)/ALDH2(1) and ALDH2(1)/ALDH2(2) genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We found that the frequencies of the alleles ADH2*2 (57%), ADH3*1 (78%) and ALDH2*2 (9%) in the alcoholic cirrhotic patients were significantly lower than those in the healthy controls and in the patients with cirrhosis from viral hepatitis and with gastric and duodenal ulcer.(ABSTRACT TRUNCATED AT 250 WORDS)]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We aimed to clarify the influences of aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 1B (ADH1B) polymorphisms, and ethanol consumption profile to hepatocellular carcinoma (HCC) development in alcoholic liver cirrhosis without chronic hepatitis B and C virus infection (non-B non-C).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Understanding the influences of genes involved in dopamine and serotonin metabolism, such as the aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes, is critical for understanding addictive behavior.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We evaluated associations between ADH1B/ALDH2 genotypes and the body weight and body mass index (BMI) of 1,301 Japanese alcoholic men at the time of their first visit to an addiction center.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In comparison with the ADH1B*1/*1 and ALDH2*1/*1 genotype combination, the ADH1B*1/*1 and ALDH2*1/*2 genotype combination and the ADH1B*2 allele and ALDH2*1/*2 genotype combination increased stepwise the ORs (95% CI) for macrocytosis (1.65 [0.92 to 2.94] and 4.07 [2.33 to 7.11], respectively, p for difference in OR = 0.015) and macrocytic anemia (2.80 [1.52 to 5.15] and 5.32 [3.29 to 8.62], respectively, p for difference in OR = 0.045).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Macrocytosis and macrocytic anemia in alcoholics have been associated with ADH1B and ALDH2�gene variants which increase acetaldehyde (AcH) levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results revealed that (1) the less active allele of the ADH2 gene (ADH2*1) is associated with an increased risk for alcohol dependence, alcohol-induced persistent amnestic disorder, alcohol withdrawal syndrome, and cancer of the upper GI tract; (2) the inactive allele of the ALDH2 gene (ALDH2*2) is associated with a decreased risk for alcohol dependence, and an increased risk for alcoholic polyneuropathy and cancer in the same region; and (3) these genetic variations modify clinical features of alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Considering genotype effects under conditions of immune stimulation, we observed suppressive effects of ADH1B*2 allele on leukocytosis (?9,000/?l; 0.69 [0.50 to 0.97]), granulocytosis (?6,500/?l; 0.66 [0.47 to 0.93]), and monocytosis (?750/?l; 0.56 [0.39 to 0.79]).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1B genotype was associated with the frequency and volume of drinking but its associations with binge drinking and problem drinking were less consistent.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This suggests that drunk drivers with augmented MCV modulated by the alcohol metabolic ADH1B*1/*1 genotype may be at higher risk of driving incapability and of alcohol-related cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The proportion of individuals carrying about susceptible genotypes of alcohol-related diseases in Chinese Han healthy population should be more than one half (68.16%), which calls on reinforcing the surveillance and preventing the alcohol-related disease]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the absence of ALDH2 mutant genotype is strongly related to heavy drinking behavior. We can not prove, however, any evidence that the polymorphisms of other ethanol-metabolizing enzymes are associated with the determination of]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Studies of genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We genotyped the rs1229984 G?A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH2*1/*1 and the ADH3*1/*1 genotypes were statistically significantly more common among the patients who abuse alcohol than in the control group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The findings support a protective effect for ADH2*2 against heavy drinking in Jewish samples but also suggest the importance of environment. Future work should investigate interactions between genes and the environment in larger samples.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Among the Atayal, the group with alcohol use disorders (alcohol dependence and alcohol abuse) had a significantly lower frequency of the ADH2*2 allele (0.82) than those without alcohol use disorders (0.91).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Two conclusions may be drawn from this summary of published results. First, the ADH1B*47His allelic effects on alcohol dependence risk are not additive. Heterozygotes are clearly more similar in risk to the ADH1B*47His/*47His homozygotes than to the ADH1B]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present findings suggest that one of the genetic factors that may be related to probable AUD among Thai males living in the north-east is the ADH2 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1B gene has consistently been implicated in problem drinking, but rarely incorporated into gene by environment investigations of alcohol phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Review article]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The high prevalence of the ALDH2*2 and ADH1B*2 alleles in a large percentage of Asian subgroups has been studied as a potential protective factors against alcohol abuse, yet some individuals who possess these genes still engage in problematic alcohol use (Wall et al.2001).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[this study showed the strong effect of ADH2 His(47)Arg polymorphism on habitual drinking regardless of ALDH2 genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data strengthen the support for ADH as a candidate locus for alcohol dependence and suggest further productive study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Individuals heterozygous for ALDH2*2 exhibit strong alcohol hypersensitivity caused by persistent accumulation of large amounts of acetaldehyde, but homozygosity for ADH2*2 is not dependent upon this pathway against alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5' end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p = 0.0018 and 0.0012, respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants of this alcohol-metabolizing enzyme appeared in the relation to alcoholic chronic pancreatitis]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The chronic pancreatitis group had a significantly higher frequency of the ADH 2(2) allele than that in cases without such findings (87.5% vs. 58.7%, p < 0.05).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequency of the ADH2*2 allele in the alcoholic CP group was significantly higher than that in alcoholics without pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcoholic cirrhosis but not alcoholic chronic pancreatitis is associated with ADH3*2/*2 and perhaps with ADH2*1/*1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have compared ADH2, ADH3 and ALDH2 allele frequencies in patients with alcohol-related cirrhosis (n = 59) and chronic pancreatitis (n = 13) with 79 local healthy control subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of the present study suggest that ADH2 Arg/His genotype should be associated with a decreased risk for migraine, while the ADH2 His allelic variant should be related with the risk for triggering migraine attacks after alcohol consumption in our population of migraine patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These studies identify single locus associations with preterm birth for both maternal and fetal genotypes in two populations of European ancestry.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Inactive ALDH2 encoded by ALDH2*1/2*2 and the low-activity form of alcohol dehydrogenase (ADH)-2 encoded by ADH2*1/2*1 enhance the risk for esophageal cancer in Japanese light to heavy drinkers, a significant association that emphasizes the importance of screening tests for inactive ALDH2 based on alcohol flushing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings suggest that polymorphisms of ADH2 and ALDH2 can modify the influence of alcoholic consumption on esophageal cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol drinkers carrying both ADH2 G allele and ALDH2 A allele have a higher risk of developing esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Education regarding these risky conditions in connection with ALDH2 and ADH2 is vitally important in a new strategic approach aimed at preventing esophageal cancer in East Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcoholics' population attributable risks due to ADH2/ALDH2 polymorphisms were estimated to be 82.0% for oropharyngolaryngeal cancer and 63.9% for esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH2(1)/ADH2(1) and ALDH2(1)/ALDH2(2) genotypes were independently and significantly higher in esophageal cancer patients than in healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of the alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes are associated with the risk of esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[After adjusting for age, drinking and smoking habits, BMI and ALDH2/ADH2 genotypes, macrocytosis of MCV > or =106 fl was associated with increased risk for esophageal cancer (OR = 2.75).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, our results shed new light on the complex gene-environment interactions that exist between environmental factors and ADH2 G48A polymorphism in EC risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Compared to Zoroastrians, Turkomans had higher frequency of four alleles that are speculated to favor carcinogenesis (CYP1A1 m1, CYP1A1 m2, CYP2A6*9, and ADH2*1); these results are consistent with an influence of these allele variants on the population risk of EC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine the effects of ALDH2 and ADH2 genotypes in genetically based cancer susceptibility, lymphocyte DNA samples from 668 Japanese alcoholic men more than 40 years of age (91 with and 577 without esophageal cancer) were genotyped and the results were expressed as odds ratios (ORs).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, our findings indicated that ADH1B (rs1229984) was associated with EC independent of alcohol drinking and tobacco smoking status and alcohol drinking interacted with ALDH2 (rs671) on EC susceptibility in this high-risk Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association of lifestyle habits and polymorphism of ADH2 and ALDH2 genes with the risk of esophageal cancer in Thai population was investigated in a hospital-based case-control study: 202 cases and 261 controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that ADH1B and ALDH2 polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We speculate that increased tissue levels of toxic aldehyde could result from inactive ALDH2 and usual ADH2 expression, which results in the increased level of reactive aldehyde in sensory neuron pathway, thereby causing symptomatic polyneuropathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Among moderate-to-heavy drinkers, men with the less-active ADH1B*1/*1 had a significantly higher risk of the cancers overall, of hypopharyngeal cancer, and of oral/oropharyngeal cancer (OR = 5.56, 7.21 and 4.24, respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There was no association between ADH3 genotypes (ADH(1-1)(3), ADH(1-2)(3), and ADH(2-2)(3)) and risk of oral and pharyngeal cancer (odds ratios, 1.00; 0.96; 95% confidence interval, 0.68-1.37; and odds ratio, 1.23; confidence interval, 0.78-1.93, respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Despite sufficient statistical power, there was no significant impact of ADH1B and ALDH2 on the risk of breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have demonstrated that several SNPs are associated with survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For the ADH1B gene, there were statistically significant associations between all levels of alcohol intake and risk of breast cancer (all OR > 1.34 and all lower CI > 1.01), while for women with the GA or AA genotype, there were no significant associations between alcohol intake and risk of breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Neither alcohol drinking nor alcohol metabolizing ADH1B and ADH1C genotypes were associated with breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study low levels of alcohol are associated with a modest increase in breast cancer risk that is not altered by known functional allelic variants of the ADH1B and 1C gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate whether genetic polymorphism of alcohol dehydrogenase (ADH) 2 and aldehyde dehydrogenase (ALDH) 2 was related to alcoholic testicular atrophy, we determined restriction fragment-length polymorphisms of the ADH2 and ALDH2 genes in 43 Japanese male alcoholics and 50 healthy subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The allele frequency of ADH2*1 in acute pancreatitis patients was significantly lower (P < .01) than in alcoholic cirrhotic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In contrast, the ADH2 and ALDH2 allele frequencies for the AVN subgroup were more similar to those of the acute-pancreatitis than to the cirrhosis subgroup.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To clarify the impact on female breast cancer risk of the interaction of the effects of alcohol consumption and polymorphisms in the alcohol-metabolizing enzymes ADH1B and ALDH2, we conducted a case-control study of 456 newly and histologically diagnosed breast cancer cases and 912 age- and menopausal status-matched noncancer controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The increased ERK phosphorylation associated with ADH2 and uveal melanoma mutants was rectified by NPS-2143.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The presentations were (1) 4-Methylpyrazole as a tool in the investigation of the role of ADH in the actions of alcohol in humans, by Taisto Sarkola and C. J. Peter Eriksson; (2) ADH2 polymorphism and flushing in Asian populations, by Wei J. Chen, C. C. Chen, J. M. Ju, and Andrew T. A. Cheng; (3) Role of ADH3 genotypes in the acute effects of alcohol in a Finnish population, by Hidetaka Yamamoto, Kathrin Kohlenberg-M�ller, and C. J. Peter Eriksson; (4) Clinical characteristics and disease course of alcoholics with different ADH2 genotypes, by Mitsuru Kimura, Masanobu Murayama, Sachio Matsushita, Haruo Kashima, and Susumu Higuchi; (5) ADH2 polymorphism, alcohol drinking, and birth defects, by Lucinda Carr, D. Viljoen, L. Brooke, T. Stewart, T. Foroud, J. Su, and Ting-Kai Li; and (6) ADH genotypes and alcohol use in Europeans, by John B. Whitfield.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphic variation in ALDH2, XPD and MGMT genes may be of importance for ESCC susceptibility. Polymorphic variation in CYP2A6 and MGMT are associated with ESCC metastasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B/ALDH2 genotypes affect the risk of esophageal cancer, and the risk is modified by alcohol consumption, ethnicity, and gender.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[CYP2E1 (*c1/*c1), ALDH2 (*1/*2) and ADH1B (*1/*1) genotype frequencies were higher among patients with squamous cell carcinomas, at a level close to statistical significance (P=0.014; P=0.094; P=0.0001 respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of ADH1B is associated with oral and pharyngeal squamous cell carcinoma]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene-gene and gene-environment interactions between alcohol drinking habit and polymorphisms in alcohol-metabolizing enzyme genes and the risk of head and neck cancer in Japan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption. The individuals carrying both risky genotypes have a higher baseline risk of ESCC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol consumption and polymorphisms in the CYP2E1, ADH1B and ALDH2 genes are important risk factors for esophageal squamous cell carcinoma in Chinese males living in Gansu Province, China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cox proportional hazards analysis showed that the age-adjusted relative hazard for SCC was 11.55 [95% confidence interval (95% CI), 5.73-23.3] in ALDH2*1/*2 heterozygotes compared with ALDH2*1/*1 homozygotes, 2.02 (95% CI, 1.02-4.02) in ADH1B*1/*1 homozygotes compared with ADH1B*1/*2 heterozygotes or *2/*2 homozygotes, 2.64 (95% CI, 1.49-4.67) in patients with flushing compared with those who had never experienced flushing, 2.91 (95% CI, 1.63-5.20) in those with an MCV >or= 106 compared with those with an MCV < 106, 2.52 (95% CI, 1.22-5.22) in those who smoked >or=30 cigarettes per day compared with those who smoked 0 to 19 cigarettes per day, 7.26 (95% CI, 3.99-13.23) in those with esophageal dysplasia compared with those without distinct iodine-unstained lesions >or=5 mm, and 0.28 (95% CI, 0.09-0.85) in those with body mass index >or= 23.2 (highest quartile) compared with those with body mass index < 19.0 (lowest quartile).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[consumption of tobacco and alcohol, coupled with genetic susceptibilities associated with acetaldehyde elimination, as modulated by ADH1B and ALDH2 genotypes, determines a substantial magnitude of tumorigenetic effect on earlier age ESCC diagnosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Revealed by this meta-analysis, ADH1B*47Arg as a common ancestral allele can significantly increase the risk of ESCC in Asians, especially when coupled with alcohol drinking or the ALDH2*504Lys allele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Yet, polymorphisms in ADH1B or ADH1C were not significantly associated with risk of CVD in our data and after pooling results of eligible prospective studies [ADH1B*1/1: RR?=?1.35 (95% CI: 0.98-1.88; p for heterogeneity: 0.364); ADH1C*2/2: RR?=?1.07 (95% CI: 0.90-1.27; p for heterogeneity: 0.098)].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that the ADH2(1) allele may be associated with alcoholic brain atrophy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of genotype combinations showed that �ever drinking� with both ADH1B His/His and ALDH2 Lys + was the most potent risk factor for PC relative to �never drinkers� with both ADH1B His/His and ALDH2 Glu/Glu [OR (95% CI); 4.09 (1.30�12.85)].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Neither ADH1B or ADH1C polymorphisms alone nor their combinations showed a significant effect on pancreatic cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Non-drinkers or women with ALDH2 *1/*1 and ADH1B *1/*1 are likely to suffer from any mental disorder except ARD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic alcohol sensitivity, especially that with the genotype combination of ALDH2(*)1/(*)1 and ADH1B(*)1/(*)1, was significantly associated with an increased risk of depressive and anxiety disorders as well as ARD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Protective effects of the alcohol dehydrogenase-ADH1B allele in children exposed to alcohol during pregnancy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple ADH genes are associated with upper aerodigestive cancers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Risk of cerebral infarction is increased by the ADH2*1 allele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple regression analyses confirmed that the risk of lacunae and cerebral infarction was increased by the ADH2*1 allele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

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[Moreover, the frequency of ADH2(2)/2(2) genotype was significantly higher in autopsy cases with interlobular fibrosis in the pancreas, which suggests alcoholic pancreatic damage, than in cases with only intralobular pancreatic fibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of ADH1B and ALDH2 variants is valuable for secondary prevention of OSCC in high-risk patients who smoke and drink alcohol. In this study, SNP genotyping demonstrated that the ADH1B and/or ALDH2 risk alleles had an interaction with smoking and, e]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There are also significant gene-gene and gene-environment interactions between drinking and ADH2 and ALDH2 polymorphisms regarding CRC risk in Chinese males.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Moreover, the SNPs rs1229984 in ADH1B gene was found to be associated with CRC risk: under the recessive model, the OR was 1.75 for A/A genotype (95%CI = 1.21-2.52; p-value = 0.0025).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms were not associated with CRC risk overall in Western-European populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It is unlikely that acetaldehyde metabolism determined by ALDH2 polymorphism contributes to the risk of colorectal cancer, whereas the role of ADH2 polymorphism deserves further investigation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[interaction between ALDH2 and ADH2 polymorphisms may have a role in colorectal cancer in Japan]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with colorectal cancer risk in Chinese males]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The interplay between alcohol consumption, oral hygiene, ALDH2 and ADH1B in the risk of head and neck cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg(48)His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21-16.11).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase-1B Arg47His polymorphism is associated with head and neck cancer risk in Asian: a meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B*2 and ADH1C*1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2*2, results in increased acetylaldehyde levels and is hypothesized to increase the risk of head and neck cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In addition, increased risk of esophageal SCC was consistently associated with the ADH2*1*2 and the p53 codon 72 Pro/Pro genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We found significant association with risk of ESCC for four SNPs, including rs1494961 in HEL308 at 4q21 [odds ratio (OR) = 1.15, 95 % confidence interval (CI) = 1.05-1.26], rs1229984 in ADH1B at 4q23 (OR = 1.24, 95 % CI = 1.13-1.36) and rs1789924 near ADH1C at 4q23 (OR = 1.20, 95 % CI = 1.03-1.39), and rs671 in ALDH2 at 12q24 (OR = 0.83, 95 % CI = 0.75-0.91).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In our previous study, we found that polymorphisms of alcohol and aldehyde dehydrogenase (ADH1B and ALDH2) are important risks for esophageal squamous cell carcinoma in a Taiwanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, the interplay of the ADH1B and ALDH2 genotypes, in conjunction with a behaved drinking habit and a practiced drinking pattern, along with continued tobacco consumption, plays an important pathogenic role in modulating ESCC risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The inactive ALDH2 encoded by ALDH2*1/*2 and the less-active ADH1B encoded by ADH1B*1/*1 increase the risk of esophageal squamous cell carcinoma in East Asian drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Esophageal squamous cell carcinoma and ALDH2 and ADH1B polymorphisms in Chinese females.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The risk of the ESCC in moderate-to-heavy drinkers with ALDH2 (*1/*2) combined the ADH1B (*1/*1) genotype or ALDH2 (*1/*2) combined the CYP2E1 (*c1/*c1) genotype leads to synergistic interactions, higher than drinkers with ALDH2 (*1/*1)+ADH1B (*1/*2+*2/*2), ALDH2 (*1/*1)+CYP2E1 (*c1/*c2+*c2/*c2) respectively , ORs (95% CI) of 7.46 (3.28-18.32) and 6.82 (1.44-9.76) respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Furthermore, persons with the combined genotypes ADH2(1)/ADH2(1) and ALDH2(1)/ALDH2(2) were at extraordinarily high risk for esophageal squamous cell carcinoma, with an odds ratio of 17.9 (p < 0.001).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We confirmed the known association of the ALDH2 locus on 12q24 to ESCC, and a joint analysis showed that drinkers with both of the ADH1B and ALDH2 risk alleles had a fourfold increased risk for ESCC compared to drinkers without these risk alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The histidine allele at codon 48 of ADH1B gene was associated with a significantly decreased risk of ESCC in the joint data set (primary and validation set) under a recessive model (odds ratio, 0.41; 95% confidence interval, 0.29-0.76; P = 4 x 10(-4)).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We identified the significant associations of ESCC with 4q21-23 and 12q24 regions, which include nonsynonymous single nucleotide polymorphisms (SNP) in ADH1B (rs1229984, P = 6.76 x 10(-35)) and ALDH2 (rs671, P = 3.68 x 10(-68)) that were previously shown to be associated with ESCC susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Japanese alcoholic men with (n = 65) and without (n = 206) esophageal squamous cell carcinomas, excluding those with liver cirrhosis, were assessed for MCV within 7 days of their last drink, alone or in combination with findings from either the alcohol flushing questionnaire or genotyping to identify inactive aldehyde dehydrogenase-2 (ALDH2*1/2*2) and the less-active form of alcohol dehydrogenase-2 (ADH2*1/2*1), which pose risks for esophageal squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It has also been reported that inactive ALDH2*1/*2 and less-active ADH1B*1/*1, and smoking, are risk factors for esophageal SCC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Joint effects of eNOS gene T-786C and ADH2 Arg47His polymorphisms on the risk of premature coronary artery disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The selected ADH and ALDH gene variants had only minor effects, and did not seem to markedly modify the health effects of alcohol drinking. The observed statistical significant associations would not be significant, if corrected for multiple testing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Carrying the alcohol dehydrogenase 1B 48His allele (rs1229984 or ADH1B*2) could decrease the risk of alcoholism, but with persistent drinking may confer a greater risk of CLDs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[' The frequency of proteinuria and the percentage of proliferative retinopathy among the patients with retinopathy was higher in those with active ALDH2 and superactive ADH2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Since many factors such as the ALDH2*1 gene and ADH2*2 gene, daily drinking habits, exercise, and dehydration enhance the increase in plasma concentration of uric acid induced by ethanol, it is important to pay attention to these factors, as well as ingested ethanol volume, type of alcoholic beverage, and the administration of anti-hyperuricemic agents, to prevent and treat ethanol-induced hyperuricemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B*2 allele is protective against alcoholism but not chronic liver disease in the Hungarian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germline loss- and gain-of-function mutations of G-protein ?-11 (G?11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium (Ca(2+) i) signaling, lead to familial hypocalciuric hypercalcemia type 2 (FHH2) and autosomal dominant hypocalcemia type 2 (ADH2), respectively, whereas somatic G?11 mutations mediate uveal melanoma development by constitutively up-regulating MAPK signaling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The triangular association of ADH1B genetic polymorphism, alcohol consumption and the risk of depression in older men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that the ADH2*1/2*1 genotype is a risk factor for the development of WKS in alcoholic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore, we hypothesized that expression of different ALDH2 and ADH2 polymorphisms may induce differences in vascular complications in diabetes and conducted two studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The faster metabolism of ethanol and acetaldehyde by the ADH1B*2 allele and ALDH2*1/*1 genotype and higher ketosis levels were associated with higher UA levels in alcoholics, while diabetes and the consumption of sake were negative determinants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To ascertain why alcohol is prone to manifest unpleasant effects in diabetes associated with mitochondrial tRNA(Leu(UUR) mutation at position 3243 (DM-Mt3243), we investigated the genotype of aldehyde dehydrogenase (ALDH) 2 and alcohol dehydrogenase 2 (ADH2) in DM-Mt3243.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1B*2 allele increased the AORs for LC, CP, and DM of the alcoholics, and the ALDH2*1/*1 genotype increased their AORs for LC, DM, and HT.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, the frequencies of ADH2 genotype in the DM-Mt3243 group, the normal control subjects, and the NIDDM control subjects were not different.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that genotypes of ADH2 and ALDH2 can modify the diabetic risk, irrespective of amounts of alcohol consumed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The restriction fragment-length polymorphisms of the ADH2 and the ALDH2 genes were analyzed in 47 normal subjects and 31 patients with alcoholic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We speculate that the ADH1B*1 gene may function by reducing vulnerability to the onset of alcoholic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, ALDH2*1 is the most important alcohol metabolizing gene affecting predisposition to alcoholism whereas the ADH2*2 gene may influence susceptibility to acute alcoholic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that the risk of chronic alcoholic pancreatitis diagnosed clinically and pathologically seems to be associated with the ADH 2(2) allele in the genotypes of alcohol-metabolizing enzymes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that the risk of alcoholic pancreatitis seems to be associated with the presence of ADH2(2)/2(2) genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings are consistent with the hypothesis that enhanced sensitivity to alcohol and lower levels of alcohol use reflect the mechanism by which ADH1B*2 protects against developing an AUD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We evaluated associations between ADH1B/ALDH2 genotypes and the blood EtOH levels of 805 Japanese alcoholic men in the morning after they had drunk within the previous 34 h.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings provide further strong evidence for the involvement of the ADH1B gene in the pathogenesis of alcohol dependence and abuse as well as for some alcohol-induced medical diseases in the multiple ethnic populations--in particular, certain Asian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The specific aim of the study was to investigate the associations between the presence of the ADH2* 3 allele and personal and family history of alcohol use/abuse.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH2*2, however, was not related to alcohol use disorders, alcohol-induced flushing and associated symptoms, number of binge drinking episodes in the past 90 days, maximum number of drinks ever consumed, or self-reported levels of response to alcohol.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B rs1229984 polymorphism HRs for HNC and oesophageal cancer death and for alcohol related cancer death were 0.67 (95% CI: 0.42-1.08), and 0.64 (95% CI: 0.40-1.03), respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Compared with individuals carrying both ALDH2 G/G and ADH2 A/A alleles and with a cumulative amount of alcohol consumption <2.5 (kg * years), drinkers carrying both ALDH2 A and ADH2 G alleles and with a cumulative amount of alcohol consumption > or =2.5 (kg * years) showed a significantly elevated risk of esophageal cancer (OR=53.15, 95% CI: 4.24-666.84).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results revealed that it was not ADH2 but ALDH2 polymorphisms and drinking alcohol had a significant interaction with the development of esophageal cancer, suggesting that in order to help lowering the risk of esophageal cancer, individuals who are carrying ALDH2 A/A or G/A genotypes should be encouraged to reduce their consumption of alcohols.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It was observed that ADH variants, ADH2*1 and ADH3*2, were associated with increased risk for oesophageal cancer, possibly due to the tolerance of the carriers of these alleles to alcohol consumption compared to those with high activity alleles (ADH2*2 and ADH2*3) which are associated with higher production of the unpleasant acetaldehyde intermediate.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that the ADH1C allele modifies the carcinogenic dose response for alcohol in the upper aerodigestive tract, giving rise to a gene-environment interaction. The role of genes as possible modifiers of life-style risks seems the most relia]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study examined the joint effects of variation in ADH1B and childhood adversity-a well-documented risk factor for alcohol problems and moderator of genetic liability to psychiatric outcomes-on maximum drinks consumed in a 24-hour period (maxdrinks) and alcohol use disorder (AUD) symptoms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The longer-than-expected EtOH lingering in the blood of the ADH1B*1/*1 alcoholics may exacerbate alcohol-related problems, including drunk driving.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in Japanese population but their significance for CRC carcinogenesis remains to be clarified in detail.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase-2 (ADH2) and aldehyde dehydrogenase-2 (ALDH2) gene polymorphisms play roles in ethanol metabolism, drinking behavior and esophageal carcinogenesis in Japanese; however, the combined influence of ADH2 and ALDH2 genotypes on other aerodigestive tract cancers have not been investigated.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings demonstrate that CaSR-targeted compounds can rectify signaling disturbances caused by germline and somatic G?11 mutations, which respectively lead to calcium disorders and tumorigenesis; and that ADH2-causing G?11 mutations induce non-constitutive alterations in MAPK signaling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The decrease in PBL-TL modulated by the alcohol metabolic genotype ADH1B*1/*1 may represent a novel mechanism potentially related to alcohol carcinogenesis in alcohol abusers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A path analysis based on structural equation modeling showed a direct effect of ADH1B gene polymorphisms on colorectal carcinogenesis and also an indirect effect mediated through alcohol consumption.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study examined additive and interactive effects of ALDH2 and ADH1B genotypes on drinking behavior in a mixed-gender sample of Asian young adults, focusing on continuous phenotypes (e.g., heavy episodic and hazardous drinking, alcohol sensitivity, drinking consequences) whose expression is expected to precede the onset of alcohol use disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore, among those at risk for greater consumption, e.g. those who experienced childhood adversity, ADH1B-rs1229984 appears to have a stronger effect on alcohol consumption and consequently on risk for AUD symptom severity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that studies searching for genes relating to the LR to alcohol as a vulnerability factor for AUDs should consider controlling for ADH1B genotype, as the ADH1B*2 allele could obscure the impact of other genetic polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Because family history of alcoholism is one of the best predictors of the development of alcohol use disorders, this pilot study suggests that, in this sample of African American young adults, the ADH2*3 allele may be associated with a lowered risk for the development of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For example, among those without protective alleles for ADH1B or ADH1C, OR for AUD was 1.87 as compared to those without the protective allele for ADH1B only and was 3.16 as compared to those with protective alleles for both ADH1B and ADH1C.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, it remains unclear whether ADH1B*2 contributes significantly toward the accumulation of systemic blood acetaldehyde and whether it plays a critical role in the alcohol flushing reaction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ALDH inactive form resulting from ALDH2*2, which slows the elimination of acetaldehyde and the more active isozymes produced by ADH1B*2, could generate higher acetaldehyde levels and thus deter heavy drinking ().]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[By contrast, allelic variations in ADH1B exerted no significant effect on HDS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Finally, because slow ADH1B alcohol degradation is found in more than 90% of the white population compared to less than 10% of East Asians, the population attributable risk of heavy drinking and alcoholism by ADH1B.1/1 genotype was 67 and 62% among the white population compared with 9 and 24% among the East Asian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Similarly, a significantly increased risk of heavy drinking was observed for each haplotype compared with ADH1B*2(rapid)-ADH1C*1(rapid).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The findings support a protective effect for ADH2*2 against heavy drinking in Jewish samples but also suggest the importance of environment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Furthermore, in the presence of ALDH2*1/2*2, the risks for multiple intra-esophageal cancers (OR = 3.43) and for esophageal cancer with oropharyngolaryngeal and/or stomach cancer (OR = 3.95) were higher than the risks for solitary intra-esophageal cancer and for esophageal cancer alone, but these tendencies were not observed for ADH2*1/2*1 genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of ADH1B, ADH1C and ALDH2, alcohol consumption, and the risk of gastric cancer: the Japan Public Health Center-based prospective study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In a population-based study of 305 cases and 428 controls in Warsaw, Poland, we evaluated the effect of polymorphisms in alcohol metabolizing genes, including ADH1B (Ex9+5C>T, Ex3+23A>G, Ex3+58A>T and Ex9+77A>G), ADH1C (Ex8-56A>G and Ex6-14G>A) and ALDH2 (Ex1+82A>G), on levels of alcohol drinking and susceptibility of stomach cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, ADH2 genetic polymorphisms may not be important dominants of susceptibility to gastric cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Heavy drinker status was also strongly associated with ADH2 Arg alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Roles of the genetic variation of alcohol-metabolizing enzymes on biomarkers in trauma patients with excessive alcohol intake at emergency department.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An analysis of combined effect indicated that GG genotype of ADH2 G48A was associated with the highest risk of EC in heavy drinkers and smokers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Higher responses on the SHAS items muddle/confused and nauseated were significantly associated with the presence of at least one ADH1B*3 allele following the high dose of alcohol in Afro-T. Indo-T with at least one ADH1C*2 allele displayed significantly different Drug � Time interactions for the SHAS item effects of alcohol at the low dose and for the SHAS items clumsy, muddle/confused, effects of alcohol, floating, drunk, and total at the high dose from Indo-T with two ADH1C*1 alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In subgroup analyses according to smoking and alcohol drinking status, the OR of the ADH1B*1*1 genotype was increased in the heavy drinker group [8.85 (1.095-40.0)] and in the heavy smoker group [4.7 (1.54-14.29)].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that the ADH1B*1*1 genotype is associated with an increased risk of SCCHN, especially in heavy drinkers and heavy smokers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We assessed the main and additive interactive effects of childhood adversity (abuse, neglect and parental divorce) and the ADH1B-rs1229984 on the quantitative phenotypes 'maximum drinks in a day' (Maxdrinks) and DSM-Alcohol Use Disorder (AUD) severity, adjusting for demographic variables, in an Israeli sample of adult household residents (n?=?1143) evaluated between 2007 and 2009.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The alcoholics had significantly lower frequencies of the ADH2(2) and ALDH2(2) alleles than did the nonalcoholics, suggesting the inhibitory effects of these alleles for the development of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recently, the contributions of alcohol dehydrogenase-2 (ADH2) polymorphism to alcoholism, esophageal cancer, and the flushing response have also been described.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that the alleles ADH2*2 and ADH3*1, coding for the high-Vmax beta 2-ADH and gamma 1-ADH, respectively, may play a protective role against alcoholism in Chinese patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B*2 is most often observed in Asian populations, and has been shown to be protective against alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Studies have demonstrated that a certain variant of the gene encoding ADH1B (ADH1B*3) is associated with a reduced risk of alcoholism in Afro-Trinidadians, as is a variant of the gene encoding ADH1C (i.e., ADH1C*1) in Indo-Trinidadians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the Mae III polymorphisms of the ADH2 gene may be associated not only with susceptibility to alcoholic liver cirrhosis, but also with the development of alcoholism in Japanese patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We develop a pharmacokinetic model describing how genetic variations in ADH1B, ADH1C, ADH7, ALDH2, and TAS2R38 affect consumption behavior, and alcohol and acetaldehyde levels over time in various tissues of individuals with a particular genotype to predict their susceptibility to alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Individuals with alcohol dependence are less likely to possess variant alleles of the alcohol-metabolizing genes, aldehyde dehydrogenase (ALDH2*2) and alcohol dehydrogenase (ADH1B*2), than non-alcohol-dependent controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, the frequency of the ADH2*2 allele was significantly lower in male Japanese classified as alcoholic on the basis of the Kurihama Alcoholism Screening Test than in nonalcoholic males.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Regular male drinkers without alcohol dependence (n = 112) ages 18-25 years participated in alcohol challenge sessions consisting of placebo and two doses of alcohol (target BrAC: 0 g/dl for placebo, .04 g/dl low dose, and .08 g/dl high dose) and genotyped for variants in ADH1B*3 and ADH1C*2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that, while the risk of alcoholism in Korean men is predominantly affected by the presence of the ALDH2 1/1 genotype, the risk of alcoholism in Korean women is primarily associated with the ADH2 1/1 genotype and G carrier genotype of the OPRM1 A118G polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In Taiwan, about 70% of the Han Chinese population have the ADH2*2 allele and 50% show ALDH2*1/*2 or ALDH2*2/*2 genotypes, which offer protection against drinking behavior and the risk of developing alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that the lower rates of alcohol dependence in those with ADH1B*3 alleles may be because of differences in alcohol response, particularly increased sedation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The males bearing alcoholism-susceptible homozygotes at both loci (inactive ADH1B Arg/Arg and active ALDH2 Glu/Glu genotypes) have a 10 times greater risk for suicide compared with the males bearing alcoholism-protective homozygotes at both loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The key findings of the earlier studies were that variations (i.e., polymorphisms) in the DNA sequences of the genes encoding alcohol dehydrogenase 1B (i.e., the ADH1B gene), aldehyde dehydrogenase 2 (i.e., the ALDH2 gene), and other alcohol-metabolizing enzymes mediate the risk for alcoholism; moreover, these polymorphisms also have an impact on the risk of alcohol-related cancers, such as esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[On an individual level, however, the genotypes controlling alcohol metabolism did not account for intragroup differences in vulnerability to alcoholism except in the case of ADH2 for the Ami ethnic group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased risk for alcoholism was shown in individuals with homozygous ALDH2(1) and the ADH2(1) allele (p < 0.001), but the relative risk was less than 1 in those with the homozygous ADH2(2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of two genetic variants in ALDH2 and ADH1B in AD risk has been extensively investigated.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To date, the only genes that have been consistently replicated across racial and ethnic groups to influence alcoholism vulnerability are polymorphisms in the alcohol-metabolizing enzymes, i.e. cytosolic alcohol dehydrogenase 1B (ADH1B) and mitochondrial aldehyde dehydrogenase 2 (ALDH2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We assume ADH2*1 plays an important role in the development of alcoholism in alcoholics with the heterozygous ALDH2*1/2 genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The absence of strong LD between the functional variation in ADH1B that is strongly associated with alcoholism and any of the variation in ADH7 supports the genetic independence of ADH7 in association studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The presence of the less-active form of alcohol dehydrogenase-1B encoded by ADH1B*1/*1 (vs. *2 allele) and active form of aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/*1 (vs. *2 allele) increases the risk of alcoholism in East Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequencies of the alleles ADH(2)2 and ADH(3)1, coding for the high-Vmax beta 2- and gamma 1-ADH respectively, and of the mutant ALDH(2)2 in the Oriental subjects with alcoholism or alcoholic cirrhosis are significantly lower than those in healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genes in alcohol metabolism pathway, especially ADH1B and ALDH2, conferred the major genetic risk for AD in Taiwanese Han population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH2 status was not related to alcohol dependence with ALDH2 included, and no interactions were significant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association between two functional polymorphisms in alcohol dehydrogenase (ADH2/ADH1B) and aldehyde dehydrogenase (ALDH2) genes and alcohol dependence was examined in 182 Chinese and Indian patients undergoing treatment for alcohol dependence and 184 screened control subjects from Singapore.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Ethnicity and ALDH2 status, but not ADH1B status, consistently explained significant variance in alcohol consumption in this relatively young sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1B*2 allele may protect from alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, the isozymes encoded by ADH2*2 and ALDH2*2 have been found to influence alcohol drinking behavior or alcoholism substantially.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study suggests, in this sample of Trinidadians, that the ADH1B(*)3 allele is associated with protection from the development of alcoholism but is also associated with enhanced risk for elevated serum ALT levels in those individuals who do become alcohol dependent.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: a pilot study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Major genetic components underlying alcoholism in Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Results suggest that Ashkenazic Jewish Americans with ADH2*2 alleles drink less frequently, which might contribute, in part, to the overall lower rates of alcoholism in this population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A linkage disequilibrium (LD) between the alcohol-dehydrogenase 1B (ADH1B) and alcohol-dehydrogenase 1C (ADH1C) polymorphisms adds complexity to differentiating the significance of these two genetic polymorphisms on drinking behavior and alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequencies of ADH2*1 and ADH3*2 alleles were significantly higher in men with type II alcoholism than in men with type I alcoholism and healthy men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It is clear that possession of the ADH2-2 allele decreases the risk of alcohol dependence, but it increases the risk of alcoholic liver disease among alcoholics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results indicate that self-reported flushing is determined by both ALDH2 and ADH2 and that prediction of ALDH2 genotype on the basis of self-reported flushing and nausea can help identify subjects at increased risk for alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Three mQTLs (rs2173201, rs4147542, and rs4147541 in ADH1B-AHD1C gene cluster region) found in AAs were previously identified by our genome-wide association studies as being significantly associated with AD in AAs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This brief increase (burst) in arterial acetaldehyde concentration after ethanol ingestion may constitute the mechanism by which humans carrying the ADH1B*2 allele are protected against alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Based on incidence cases of alcoholism among aboriginal Taiwanese, this study confirms the significant roles of anxiety disorders and of the ADH2*1 allele as antecedents of alcoholism among specific age and sex groups.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The current study examined self-report level of response to alcohol, ALDH2 and ADH1B, country of origin, and family history of alcoholism in 154 Chinese- and 181 Korean-American college students.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In case-control analysis, ADH1B rs1229984 (H47R) showed the most significant association with the risk of AD (p = 2.63 � 10(-21), OR = 2.35).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[After stratification by the relevant genotypes of ADH2, ADH3, and ALDH2 no significant association exists between the genetic variants at the DRD2 locus and alcoholism in the Chinese Han population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It has been well documented that variant alleles of both ADH1B*2 of alcohol dehydrogenase (ADH) and ALDH2*2 of aldehyde dehydrogenase (ALDH) protect against the development of alcoholism in East Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We developed a time- and cost-effective multiplex allele-specific polymerase chain reaction (AS-PCR) method based on the two-step PCR thermal cycles for genotyping single-nucleotide polymorphisms in three alcoholism-related genes: alcohol dehydrogenase 1B, aldehyde dehydrogenase 2 and ?-opioid receptor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol-metabolising genes and alcoholism among Taiwanese Han men: independent effect of ADH2, ADH3 and ALDH2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We found evidence for the association of several ADH genes with AD in a sample of Western European origin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants of three genes encoding alcohol-metabolizing enzymes, the aldehyde dehydrogenase gene ALDH2 and the alcohol dehydrogenase genes ADH1B and ADH1C, have been associated with reduced rates of alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Haplotype tag SNPs were selected for the block in the ADH4 gene that provided evidence of association and subsequently used in association analysis; the haplotype was significantly associated with alcoholism (P=0.01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequency of ADH2 * 1 was significantly higher in alcoholisms (ALD group and alcohol-dependent group) than in healthy controls ( P < 0.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B*1/*1 carriers tend to experience less intense alcohol flushing and are highly susceptible to heavy drinking and alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The effects of genetic polymorphism of aldehyde dehydrogenase-2 (ALDH2) on alcohol metabolism are striking in nonalcoholics, and the effects of genetic polymorphism of alcohol dehydrogenase-1B (ADH1B) are modest at most, whereas genetic polymorphisms of both strongly affect the susceptibility to alcoholism and upper aerodigestive tract (UADT) cancer of drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The hypothesized mechanism underlying the associations of the ADH1B and ALDH2 polymorphisms with alcohol dependence is that the isoenzymes encoded by these alleles lead to an accumulation of acetaldehyde during alcohol metabolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Although the ALDH2*2 variant allele has been widely accepted as protecting against the development of alcoholism in Asians, the association of the ADH1B*2 variant allele with drinking behaviour remains inconclusive.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The allele frequency of ADH2*2 (4.3%) and ALDH2*2 (0%), which are considered as protective alleles against alcohol drinking, is very low in Mexican Americans and no association is found between these alleles and alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DRD2 Ins was associated with alcoholism in those alcoholics who carried the ADH1B*2 or ADH1C*1 protective alleles (p = 0.032 in genotype level and p = 0.015 in allele level).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in the proximal promoter region of ADH1B that were associated with alcoholism were explored.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in ADH1B are protective against alcoholism in these two populations; however, these findings do not explain the high prevalence of alcoholism in these populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) affect susceptibility to alcoholism and may affect body weight via gene-associated differences in fuel utilization in alcoholics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, there was heterogeneity between studies in alcoholism for ADH2, ADH3, and ALDH2, and lack of bias in all polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B*2, ADH1B*3 and ADH1C*2) that significantly affect the risk of alcohol dependence are rare variants in most populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol-metabolizing enzymes, such as alcohol dehydrogenase-1B and aldehyde dehydrogenase-2, are the most well-established genes that have polymorphisms associated with the risk for alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) polymorphisms, specifically the ADH3*1, ADH2*2, and ALDH2*2 genotypes appear to confer a protective effect against alcoholism, most notably in Oriental subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the PCA group, the combination of the DRD2 A1 genotypes and the ADH2 1 homozygotes was strongly associated with alcoholism (P =.0027).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Controlling for group and other potentially confounding factors, ADH2*2 was associated with a lower lifetime DSM-IV alcohol dependence severity, although this differed somewhat within groups.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Logistic regression analyses of the remaining six combinatorial genotypes of the polymorphic ADH2 and ALDH2 loci indicated that individuals carrying one or two copies of ADH2*2 and a single copy of ALDH2*2 had the lowest risk (ORs 0.04-0.05) for alcoholism, as compared with the ADH2*1/*1 and ALDH2*1/*1 genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the current study, variants at ADH1B (previously ADH2), ADH1C (previously ADH3), and ALDH2 were assayed in DNA extracts from participants belonging to a Southwest American Indian tribe ( n=490) with a high prevalence of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Adh2 and cyp2e1 genetic polymorphisms: risk factorsfor alcohol-related birth defects]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Since substance dependence requires interaction of multiple genes, the combination of genotypes ADH2 * 2, CYP2E1 * 1 combined with genotype homozygous ALDH2 * 1 found in this study could be leading to the population to a potential risk to alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that variants in the ADH1B and ADH4 genes may be protective against the development of some symptoms associated with alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We hypothesized that the ADH1B and ALDH2 genes might interact with the DRD2 gene and that the association between the DRD2 gene and alcohol dependence might be affected by different ADH1B and ALDH2 genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The attributable fraction of those genetic factors, calculated based on population controls, indicates that alcoholism in 86.5% of alcoholic patients can be attributed to the detrimental effect of ADH1B*47Arg and/or ALDH2*487Glu in Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple logistic regression analyses suggest that ADH1B*2 and ALDH2*2 may independently influence the risk for alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In view of this association and the known genetic influences on both alcohol pharmacokinetics and alcohol dependence, it is probable that part of the heritability of dependence is mediated by genes (other than the known ADH2 and ADH3 polymorphisms) affecting alcohol metabolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results are consistent with genetic linkage studies showing protective associations for alcohol dependence and related behavior on chromosome 4 and suggest that ADH2 polymorphisms may account for these findings.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genes ADH1B and ADH1C have certain functional SNPs that are related to alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Previous studies have shown that the ADH1B*47His allele at one of the seven genes in humans is associated with a decrease in the risk of alcoholism and the core molecular region with this allele has been selected for in some East Asian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study examined the allele frequencies at the ADH1, ADH2, ADH3 and ALDH2 loci in Alaska Natives entering treatment for alcoholism to determine if allele frequencies at these loci differ among five distinct Alaska Native groups: Yupik and Inupiat Eskimos, Athabascan, Tlingit and Aleut.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In men, effects of alcohol dehydrogenase ADH2*1/*2 genotype or high alcohol sensitivity (risk-decreasing), and of history of childhood conduct disorder, or having monozygotic co-twin or twin sister with AlcD (risk-increasing) were significant and comparable in magnitude.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In Caucasian Spanish women the ADH1B*2 allele modulates the risk for alcohol dependence and for alcoholic liver disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In young male New Zealand Maori, the ADH2*2 allele is a protective factor against alcoholism even in the absence of ALDH2*2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For example, certain ADH1B and ADH1C alleles encode particularly active ADH enzymes, resulting in more rapid conversion of alcohol (i.e., ethanol) to acetaldehyde; these alleles have a protective effect on the risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The alcohol dehydrogenase 1B (ADH1B) genotype affects the risk for alcoholism, with elevated prevalence of a protective allele in Jews.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relation of genotypes of alcohol metabolizing enzymes and mortality of liver diseases in patients with alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Logistic regression analysis of the combinatorial genotypes of ADH2 and ALDH2 in 420 alcohol-dependent and 689 nonalcohol-dependent subjects indicated that risk for alcoholism was 100-fold lower for the ADH2*2/*2-ALDH2*2/*2 individuals than the ADH2*1/*1-ALDH2*1/*1 individuals.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the ADH2*3 allele with greater alcohol expectancies in African-American young adults.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies between neurotransmitter gene variants and alcoholism are at an earlier stage than with ADH2(2)/ALDH2(2), but results are thus far negative (dopamine DRD4 receptor), equivocal (dopamine DRD2 receptor), or preliminary (tryptophan hydroxylase, 5HT2C and 5HT1Db).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The assessment based on the proposed functional window for the human ADH gene family indicates that ADH1B*3 may show some degree of protection against alcoholism and that the ADH2 functional variants appear to be negligible for this protection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH3*2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mexican-Americans have a low frequency of the protective alleles ADH1B(*)2 and ALDH2(*)2 and a relatively high frequency of CYP2E1 c2, which is associated with early onset alcoholism.(7).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The risk for alcoholism in Japanese has been accurately estimated on the basis of the genotype frequencies of ADH2 and ALDH2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Inheritance of the high-activity ADH beta2, encoded by the ADH2*2 gene, and the inactive ALDH2*2 gene product have been conclusively associated with reduced risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Results suggest that ADH1B polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH2 and ALDH2 genotypes are associated with esophageal cancer risk/1 allele and ALDH2 2 allele carriers have a much higher risk of developing esophageal cancer, especially among alcohol drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The functional polymorphisms ADH1B rs1229984 may contribute to susceptibility to esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A review of case-control studies of the effects of ALDH2, ADH2 and ADH3 genotypes shows consistently positive associations between inactive heterozygous ALDH2 and the less-active ADH2 genotypes and the risk for esophageal cancer in East Asian heavy drinkers and this enzyme-related vulnerability may extend to light-to-moderate drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[, the interplay of the ADH1B and ALDH2 genotypes, in conjunction with a behaved drinking habit and a practiced drinking pattern, along with continued tobacco consumption, plays an important pathogenic role in modulating ESCC risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Women with inactive ADH1B and ALDH2 should reduce drinking and increase their intake of vegetable and fruit to prevent development of esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Significant gene-environment interactions between alcohol drinking and both ADH2 and ALDH2 were observed regarding esophageal cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine whether different alleles of the ADH2 gene (ADH2-1, ADH2-2 and ADH2-3) with differing levels of enzymatic activity can alter the risk of fetal alcohol effects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH2*2 allele is significantly more common in control individuals, suggesting that it may either confer protection or be a marker for a protective effect against FAS among individuals of mixed ancestry in the Western Cape Province of South Africa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Fetal ADH2*3, maternal alcohol consumption, and fetal growth.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These are the first observations of a significant gene-environment interaction explaining variation in facial morphology associated with ethanol use in pregnancy. This positive effect of ADH1B*3 is consistent with its known positive effect on offspring b]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Structural studies of aldose reductase and the homologous aldehyde reductase in complex with inhibitor were carried out to explain the difference in the potency of enzyme inhibition.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Higher alcohol intake (measured as amount or drinking frequency) was associated with lower risk of acute coronary syndrome; however, there was no evidence that these finding were modified by ADH1B or ADH1C genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High FABP4 and ADH1B expression is associated with significantly higher risk of residual disease in high-grade serous ovarian cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Using mRNA expression profiles retrieved from microarrays deposited in the Gene Expression Omnibus Profiles database, RT-qPCR measurement and bioinformatics analysis, we further indicated that high expression of HBB might predict a poorer 5-year survival, high expression of ALDH1A2 and ABCA8 might predict a poor outcome; while ALDH1A2, ADH1B, HBB and ABCA8, in particular the former two genes, might be associated with drug resistance, and ALDH1A2 and NELL2 might contribute to invasiveness and metastasis in ovarian cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results bridge the gap between DNA sequence variation and alcohol-related behavior, confirming that the ADH1B-Arg48His polymorphism affects both alcohol-related flushing in Europeans and alcohol intake.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mr. Cook's and Dr. Wall's paper adds another dimension to this article by presenting research on both the aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH2) genetic variants and their association with the alcohol-related flushing response that is prevalent in Asian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ALDH2*2 but not ADH1B*2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and pharmacodynamic findings.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Asian case-control studies have shown a strong relationship between the development of squamous cell carcinoma (SCC) of the esophagus and alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2*1/*2), less-active alcohol dehydrogenase-1B (ADH1B*1/*1), high mean corpuscular volume (MCV), and self-reported facial flushing in response to alcohol.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In those with the ALDH2*1/*2 genotype, the positive rate of facial flushing with one glass of beer was higher in those with ADH2*1/*2 and ADH2*2/*2 than those with ADH2*1/*1, although this was not significant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the ALDH2(1)/ALDH2(2) group, the frequency of facial flushing with one glass of beer was significantly higher in the ADH2(1)/ADH2(2) and ADH2(2)/ADH2(2) genotype than in the ADH2(1)/ADH2(1) genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To clarify the characteristics of men who had genetically inactive ALDH2 but did not report alcohol flushing, we analyzed individuals possessing the ALDH2*1/2*2 genotype and found that those who also had ADH2*1/2*1 (both cases and controls) tended not to report current flushing, and those who did not report current flushing (controls only) tended to be heavier drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Specifically, ADH1B*47His (previously ADH2-2) and ALDH2-2 have been shown to confer protection against alcoholism, presumably through accumulation of acetaldehyde in the blood and a resultant 'flushing response' to alcohol consumption.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In those homozygous for ALDH2*1, the presence of two ADH2*2 alleles correlated with slightly faster alcohol metabolism and more intense flushing, although a great deal of variability in the latter was noted.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Two SNPs were associated with SCCHN risk: ADH1B rs1229984 A allele (OR = 0.7; 95% CI, 0.6-0.9) and ALDH2 rs2238151 C allele (OR = 1.2; 95% CI, 1.1-1.4).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G-->A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C-->G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, this case-control study showed a significantly increased risk of SCCHN in subjects with the ADH2 Arg/Arg and ALDH2 Glu/Lys polymorphisms in a Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[H3 histones associated with a methylated upstream region of ADH1B were hyperacetylated in TSA-treated, but not in 5-aza-dC-treated, HepG2 cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Population of alcoholics from the Moscow Region had allele polymorphism ADG2. Genetic polymorphism AlDG2 is not typical for this group. Hypertensive reaction was registered in the majority of alcoholics in AWS. Higher systolic, pulse pressure and heart r]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The statistically significant decrease of serum very low density lipoproteins (LPVLD) level (on 9.95%, P = 0.045) and close to statistically significant decrease systolic pressure (on 6.80%, P = 0.068) and serum triglycerides level (on 6.16 of %, P = 0.05]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Compare of distributions of gene polymorphisms about alcohol metabolizing-related enzymes in five Chinese nationalities.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH3 polymorphism may modify the association between alcohol consumption and colorectal adenomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We examined folate and alcohol intake and genetic polymorphisms in methylenetetrahydrofolate reductase [MTHFR 667-->T (ala-->val) and MTHFR 1298A-->C (gln-->ala)] (associated with reduced MTHFR activity) and in alcohol dehydrogenase 3 [ADH3 (2-2) associated with decreased alcohol catabolism] in relation to risk of colorectal adenoma in the Health Professionals Follow-Up Study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, subjects with the ADH3*1 allele showed higher ADH activity and acetaldehyde-DNA adducts in lung than other subjects; thus, the ADH3*1 allele could be considered a risk factor for lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH IB expression, but not ADH III, is decreased in human lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lung cancer in humans is not associated with lifetime total alcohol consumption or with genetic variation in alcohol dehydrogenase 3 (ADH3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in ADH1C is associated with breast cancer]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Diplotype trend regression analysis showed that ADH5 and ADH6 genotypes, and diplotypes at ADH1A, ADH1B, ADH1C and ADH7 (minimal P = 0.002), were associated with DD in European-Americans and/or African-Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore, we determined whether polymorphisms in the genes coding for microsomal epoxide hydrolase (EPHX1), NAD(P)H:quinone oxidoreductase (NQO1), cytochrome P450 2E1 (CYP2E1) and alcohol dehydrogenase (ADH3) predispose to the development of CRC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1C polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study suggests that multivitamin supplement use may modify the association between folate pathway genes and colorectal cancer risk in a post-folic-acid-supplemented population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH3 polymorphism showed no measurable association with the risk of colorectal cancer on either overall analysis or stratified analysis with alcohol use.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, our findings are consistent with results of other studies, suggesting that alcohol consumption elevates the risk of adenomatous colorectal polyps. ADH3 polymorphism may modify the association between alcohol consumption and colorectal adeno]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The allele frequency of ADH2*1 and ALDH2*1 are different among subpopulations of alcoholics, suggesting that alcoholic patients with different specific types of organ damage are genetically different. The Chinese alcoholic patients with the ADH2*1 and AL]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings support that ADH1C Ile may lower the risk of AD and alcohol abuse as well as alcohol-related cirrhosis in pooled populations, with the strongest and most consistent effects in Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genotype ADH3*2/*2 was more frequent in patients with cirrhosis (40%) than blood donors (12%; OR 4.92, 95% CI 2.36-10.31) and patients with chronic pancreatitis (8%; OR 7.33, 95% CI 2.54-23.78) but was not significantly different from alcoholic controls (23%; OR 2.27, 95% CI 0.95-5.66).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Frequencies of ADH1C alleles and genotypes in a Turkish head and neck cancer population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Risk of head and neck cancer and the alcohol dehydrogenase 3 genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For isolated cleft lip with or without cleft palate (I-CL/P), TRIMM and HAPLIN both identified significant associations with IRF6 and ADH1C in both populations, but only HAPLIN found an association with FGF12.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that the positive association between alcohol consumption and CCD sensitization is universal and not specific to certain populations. The observed association between the ADH1b polymorphism and CCD sensitization may support that alcoho]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Distribution of alcohol dehydrogenase (ADH1C) genotypes in subjects with tobacco smoke-associated laryngeal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Results suggest a slightly increased risk of larynx cancer for indeividuals who have inherited the ADH1C*1 allele, however results were not at statistic significance level.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The lack of risk modification by the studied genotypes emphasizes the importance of environmental exposure to tobacco smoke and alcohol as major risk factors for laryngeal cancer in the German study population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of our study was to investigate whether the association of alcohol consumption with metabolic risk factors for CAD is related to ADH1C variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Moderate drinkers with a defective alcohol dehydrogenase type 3 (ADH3) genotype have higher high-density lipoprotein (HDL) levels and a decreased risk of coronary artery disease (CAD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH3(1-1) and GSTT1 null genotypes did not modify the risk of HCC due to alcohol intake whereas an influence of GSTM1 null genotype for high ethanol consumption was suggested.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that genotype AA may be a risk factor for UADT cancer, especially in individuals with low alcohol or tobacco consumption. However, further epidemiological case-control or cohort studies, preferably prospective, are needed to establi]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In addition, the oropharyngeal cancer patients had excess frequencies of both GSTmu(-) (62%) and ADH(3)1/ADH(3)1 (43%) relative to the control group, but these excess frequencies were not statistically significant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1C genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism in a total of 818 patients with alcohol-associated esophageal (n=123), head and neck (n=84) and hepatocellular cancer (n=86) as well as in patients with alcoholic pancreatitis (n=117), alcoholic liver cirrhosis (n=217), combined liver cirrhosis and pancreatitis (n=17) and in alcoholics without gastrointestinal organ damage (n=174).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The identification of an increased level of acetaldehyde in subjects homogenous for ADH(3)(2) genotype, may in part contribute to the higher incidence of alcohol-related damage, i.e. liver cirrhosis, associated with this ADH(3) genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, the aim of this study was to investigate genetic differences in polymorphisms of the alcohol-metabolizing enzymes ADH2, ADH3, ALDH2 and P4502E1 for subgroups of Chinese alcoholic patients, defined by diagnoses of AVN (n = 51), acute pancreatitis (n = 92) and liver cirrhosis (n = 159), and for 280 non-alcoholic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphism of alcohol dehydrogenase 3 in alcohol liver cirrhosis and in alcohol chronic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore, the aim of the current study was to investigate possible associations of MCV value with polymorphisms of ADH1C in white patients with alcohol-associated esophageal carcinoma, chronic alcoholic pancreatitis, and alcoholic cirrhosis as well as in heavy drinkers without organ damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We determined genotype and allele frequencies of ALDH2, CYP2E1, ADH2, and ADH3 in male Korean patients with alcoholic cirrhosis (n=56), alcoholics without evidence of liver disease (n=52), and nondrinkers (n=64) by using PCR or PCR-directed mutagenesis followed by restriction enzyme digestion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A much higher risk to alcoholic liver cirrhosis was observed in patients carrying a combination of wild genotypes of ADH1C (ADH1C*1/*1) and variant genotype of ADH1B (ADH1B*2/*2) or CYP2E1 (CYP2E1*5B) or null genotype of GSTM1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphism of alcohol dehydrogenase 3 in digestive tract alcohol damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism at the ADH3 locus is not a genetic factor for alcoholic cirrhosis in France.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Systems level analysis and identification of pathways and networks associated with liver fibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

Gene-disease associations inferred from animal model manually asserted gene-disease associations.
DisGeNET evidence - PREDICTED

[ADH1B and ADH1C genotypes were not associated with and did not modify the effect of alcohol on biochemical tests or risk of liver disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[, there was heterogeneity between studies in alcoholism for ADH2, ADH3, and ALDH2, and lack of bias in all polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The purpose of this paper is to assemble and evaluate existing data on the effect of genetic variation in ADH2 and ADH3 on the risk of alcohol dependence, and on the risk of alcoholic liver disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphic ADH2, ADH3 and ALDH2 genes can affect the propensity for alcohol drinking in Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PTEN identified as important risk factor of chronic obstructive pulmonary disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[examined genetic polymorphisms in the alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 genes in 505 patients with histologically confirmed lung cancer and 256 noncancer controls to determine association with alcohol drinking]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Individuals homozygous for ADH ( 3 ) (1-1) had a higher risk of each tumor type compared to individuals who had ADH ( 3 ) (2-2) or ADH ( 3 ) (1-2) genotype (OR = 1.7, 95% CI = 1.0-2.9 for esophageal and gastric cardia adenocarcinomas; OR = 1.7, 95% CI = 0.7-4.3 for esophageal squamous cell carcinoma; and OR = 2.8, 95% CI = 1.5-5.1 for non-cardia gastric cancer).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To find the relation between alcohol consumption and gastric cancer risk, it is important to consider both alcohol consumption level and ADH1C and ALDH2 polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We previously demonstrated that a functional polymorphism in alcohol dehydrogenase type 1C (ADH1C, also known as ADH3) modifies the association between moderate alcohol consumption and high-density lipoprotein (HDL) levels and risk of myocardial infarction among older men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Moderate drinkers who are homozygous for the slow-oxidizing ADH3 allele have higher HDL levels and a substantially decreased risk of myocardial infarction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In contrast, ADH1B and ADH1C genotypes were not associated with risk of myocardial infarction or with any of the cardiovascular biochemical risk factors, and there was no indication that associations between alcohol intake and myocardial infarction and between alcohol intake and risk factors were modified by genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphism of the alcohol dehydrogenase type 3 gene (ADH1C) has recently been associated with reduced risk of myocardial infarction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We analyzed the ADH1C genotype in 117 moderate alcohol consumers with breast cancer and in 111 age-matched women with alcohol associated diseases without cancer (74 cirrhotics, 22 patients with pancreatitis and 15 alcohol dependent patients).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Numerous association studies have provided compelling evidence that ADH1C gene variation (formerly ADH3) is associated with altered genetic susceptibility to alcoholism and alcohol-related liver disease, cirrhosis, or pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To find the ADH3 genotypes in the Polish population likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[mutations in genes encoding ADH1C (G78Stop) as genetic risk factors for Parkinson disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have previously presented genetic evidence for the possible involvement of alcohol and aldehyde dehydrogenases (ADH; ALDH) by identifying genetic variants in ADH1C and ADH4 that associate with PD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutational analysis of the adaptor protein 2 sigma subunit (AP2S1) gene: search for autosomal dominant hypocalcemia type 3 (ADH3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There were no significant main associations between the DNMT3b or ADH1C polymorphisms and polyp risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of aldehyde reductase AKR1A1 in the metabolism of ?-hydroxybutyrate in 1321N1 human astrocytoma cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest ADH3 genotype may be associated with risk of esophageal and gastric cardia adenocarcinomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this large, prospective study, we found little evidence that the ADH1C gamma1/gamma2 polymorphism is associated with risk of future stroke.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase type 3 (ADH3) and the risk of bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic susceptibility to distinct bladder cancer subphenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation at two polymorphic alcohol dehydrogenase loci, ADH2 and ADH3, and at the polymorphic mitochondrial aldehyde dehydrogenase locus, ALDH2, may influence the risk of developing alcoholism by modulating the rate of elimination of ethanol and the rate of formation and elimination of acetaldehyde.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH3*1 allele and the ADH3*1/*1 genotype are conducive to alcohol abuse starting at a younger age.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The findings of the present study suggest that polymorphism in associated candidate genes plays a role in the habitual use of tobacco and alcohol among Japanese men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The expression of ADH1C appeared to be increased in the activated pancreatic stellate cells in chronic pancreatitis and pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore we determined whether polymorphisms in the genes for alcohol dehydrogenase 3 (ADH3) or cytochrome p450 2E1 (CYP2E1) predispose to the development of CP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genotype ADH3*2/ADH3*2 is likely to be a protective factor for chronic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A multiple logistic model including ALDH2, ADH2, and ADH3 genotypes showed that the ADH3 genotype does not significantly affect the risk for esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of ADH1C polymorphism in increasing MCV and the potential use of MCV as a marker for esophageal carcinoma are still pending.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We did not observe association of ADH1C polymorphism with EC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There was a significant interaction of alcohol use and genotype (P = 0.05), with an estimated oral cancer risk in heavy drinkers of 7.1 (95% CI, 2.3-22.0) for homozygous variants compared with an OR of 2.3 (95% CI, 1.4-3.8) for ADH1C homozygous wild type or heterozygous individuals (controlling for smoking, age, race, and gender).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We estimated that OC risk increased by 31.5% per drink/week for the ADH3(2-2) genotype, 4.1% for the ADH3(1-2) genotype and 1.6% for the ADH3(1-1) genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH3(1-1) genotype appears to substantially increase the risk of ethanol-related oral cancer, thus providing further evidence for the carcinogenicity of acetaldehyde.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated whether ADH(3) and CYP2E1 DraI and RsaI genotypes modified the risk of UAT cancers among 121 oral cavity/pharyngeal cancer patients, 129 laryngeal cancer patients, and 172 controls, all French Caucasians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH3 genotype, alcohol intake and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pooling data within a large consortium has helped to clarify associations of SNPs with breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Because alcohol dehydrogenase 3 (ADH3) is rate-limiting in alcohol oxidation and is polymorphic, we examined ADH3 genotype in relation to alcohol intake and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lack of association of ADH1C genotype with breast cancer susceptibility in Caucasian population: a pooled analysis of case-control studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The data demonstrate that moderate alcohol consumers with the ADH1C*1 allele have an increased risk to develop breast cancer and even small amounts of alcohol increase serum estradiol levels significantly in premenopausal women especially in the midphase of the menstrual cycle.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interaction between ADH1C Arg(272)Gln and alcohol intake in relation to breast cancer risk suggests that ethanol is the causal factor in alcohol related breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus these findings suggest that the three variants of ADH1C, MnSOD and GSTM1 can be used to identify individuals who are at high risk to develop ALD and may be helpful in proper management of Indian alcoholics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Both heterozygosity for allele C2 of CYP2E1 and homozygosity for allele ADH3*2 of ADH3 are independent risk factors for ALD in alcohol abusers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1C *2/*2 genotype was associated with a possibly elevated risk for adenomatous polyps among individuals who consumed >26 g of alcohol/d (OR, 1.95; 95% CI, 0.60-6.30), whereas individuals who were wild-type for ADH1C were not at increased risk of adenoma (P interaction = 0.01).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The GSTmu(-) and ADH(3)1/ADH(3)1 genotypic combination may be a constitutional risk factor for laryngeal cancer among alcoholics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore, we found no evidence that supports a main effect of ADH3 genotype or a combined effect of alcohol and ADH3 genotype on risk of cancer of the oral cavity or pharynx.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[study suggests the association of ADH1C*2/* 2/MTHFR 677TT genotype combination as a risk factor for oral squamous cell carcinoma in alcoholics]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study suggests the association of ADH1C*2/*2/MTHFR 677TT genotype combination as a risk factor for OSCC in alcoholics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that the ADH3*2 allele confers increased susceptibility to the effect of alcohol on OSCC risk in our population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of ADH1C is associated with oral and pharyngeal squamous cell carcinoma]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It has been proposed that ADH3 genotype modifies the relationships between alcohol intake and cardiovascular disease by altering the HDL response to alcohol.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Regulation of ADH1C genotype on the association between alcohol consumption, BMI and WC was found in men from different European countries.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in ADH1C may not be associated with risk of colorectal adenoma, but may interact with nutrients in the one-carbon pathway to affect adenoma risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Consideration of ADH3 function relative to the respiratory effects of formaldehyde, as well as to other chemical and biological exposures that might act in an additive or synergistic manner with formaldehyde, might be critical to gain better insight into the association between formaldehyde exposure and childhood asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data identify ADH1C homozygosity as a genetic risk marker for colorectal tumors in individuals consuming more than 30 g alcohol per day and emphasize the role of acetaldehyde as a carcinogenic agent in alcohol-related colorectal carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol is a probable risk factor with regard to colorectal neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1c (rs1693482) fast metabolizing CC genotype was associated with an increased risk of impaired glucose tolerance (IGT)/diabetes compared to the CT and TT genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The odds ratio for genotype ADH1C*1/1 regarding the development of esophageal, hepatocellular and head and neck cancer were 2.93 (CI, 1.84-4.67), 3.56 (CI, 1.33-9.53) and 2.2 (CI, 1.11-4.36), respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We here investigated ADH1C Ile(350)Val, ADH1B Arg(48)His, ADH1B Arg(370)Cys and CYP2E1*5A PstI polymorphisms by PCR-RFLP Polymerase Chain Reaction - Restriction Fragment Length Polymorphism in 207 histopathologically confirmed HNC cases (184 males and 23 females) and 244 cancer-free controls (225 males and 19 females) admitted as in-patients in the same hospital.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data did not show that ADH3 genotypes had a significantly independent effect on the risk of HNSCC, nor did they modify the risks increased by alcohol or tobacco consumption and high-risk human papillomavirus infection. However, participants with ADH3(]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results reveal strong evidence for a gene-environmental interaction between the ALDH2-2 allele and alcohol consumption, for the risk of developing multiple LVL, resulting in the development of second ESCC in patients with HNSCC. Ultimately, increase]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analyses of the joint effects of alcohol consumption and ADH1C genotype on CHD risk and HDL cholesterol level using Cox proportional hazards models and linear models.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings do not support the hypothesis that ADH1C variants are associated with coronary heart disease risk in people who drink moderately.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The most frequent LOH was noted on 4q (ADH3) and 5p (D5S19), suggesting that loss of candidate tumor suppressor genes on these chromosomal arms may play a role in the development of cervical carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data did not show that ADH3 genotypes had a significantly independent effect on the risk of HNSCC, nor did they modify the risks increased by alcohol or tobacco consumption and high-risk human papillomavirus infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1C*2 allele, related to a slower oxidation rate, attenuates the lower diabetes risk among moderate to heavy drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that the presence of the CYP2E1 intron 6 DD genotype might confer a higher risk of alcoholic CP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For the 'alcoholism-free' outcome, we found significant linkage signals at D4S2457, D41651 (both flank ADH3), D11S2359, and D16S47 and significant linkage-disequilibrium signals at D4S2361, FABP2, D11S2359, D19S431 and D19S47-D19S198-D19S601.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results showed strong evidence of association between ADH1C Ile350Val (rs698, formerly ADH1C *1/*2) and alcohol dependence (AD) and abuse in the combined studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The numbers of patients with the homozygous y1y1 genotype, the heterozygous y1y2 genotype, and the homozygous y2y2 genotype in ADH3 who reported gastrointestinal symptoms were 20 (83%), 34 (76%), and 15 (88%), respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of this study was to investigate the differences among Chinese alcoholic patients with esophageal cancer, acute pancreatitis, and liver cirrhosis by studying the genetic polymorphisms of ADH2, ADH3, ALDH2, and P4502E1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We compared the frequencies of polymorphisms in ten genes that have been hypothesized to have a role in risk of EC (CYP1A1, CYP2A6, CYP2E1, GSTM1, GSTP1, GSTT1, ADH2, ADH3, ALDH2, and O6-MGMT) among three Iranian ethnic groups with highly varying rates of EC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further, these findings help clarify the mixed results from previous studies by showing that ADH1B and ADH1C jointly effect AUDs, but not consumption.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations of alcohol dehydrogenase (ADH) gene polymorphisms (ADH1B*2 and ADH1C*1) with a lifetime alcohol use disorder (AUD) were examined in White college students.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Furthermore, individuals with ADH1C slow vs fast alcohol degradation had a higher risk of heavy and excessive drinking.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study of alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1C GG genotype was associated with heavy drinking and a positive CAGE test (OR 1.34; 95% CI 1.05-1.72).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Indo-T with at least one ADH1C*2 allele may be at higher risk for heavy drinking by feeling less of the effects of alcohol, including nausea.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, the regulation of ADH3 activity may be important in preventing alcoholism development.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1C*2/*2 /MTHFR 677TT genotype combination showed the maximum risk (odds ratio 20; 95% CI = 13.45-26.64) in the heavy drinker group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recently, using ADH3-null mutant mice, we demonstrated that ADH3 (Class III), which has a high K(m) and is a ubiquitous enzyme of ancient origin, contributes to systemic alcohol metabolism in a dose-dependent manner, thereby diminishing acute alcohol intoxication.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADH1C*2/*2/MTHFR 677TT genotype combination appears to be more susceptible for OSCC, since it showed a 20-fold increase in risk in heavy drinkers and a 5.9- and 2.8-fold increase in risk respectively in moderate drinkers and light drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study suggests that the same quantitative trait locus on the chromosome 4 q region, where ADH3 is located, may influence the risk of alcoholism, variations of electroencephalogram, and the 4 ttdts of the event-related potential measures.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Studies of the ADHIBand ADH1C haplotypes, however, have shown that ADH1C*I is in linkage disequilibrium with ADHiB*2, and the ADH1C*i allele does not appear to have significant unique associations with alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No associations between alcohol dependence and polymorphisms in ADH1C were found.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[for ADH1B and ADH1C genotypes among men and women were similar.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the absence of the c2 allele, ADH3 genotype does not influence the risk of advanced alcoholic liver disease but, in males at least, may influence the risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this report we determined the genotypes for three genes, ADH2, ADH3, and ALDH2 among subjects with alcohol dependence (n = 159) and ethnically matched normal controls (n = 149) for the four largest aboriginal groups (Atayal, Ami, Bunun, and Paiwan) in Taiwan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the Polish men examined, ADH1C*1 and ADH1B*1 alleles and ADH1C*1/*1 and ADH1B*1/*1 genotypes favor alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1C*2 allele may contribute to the variance in heritability of alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evidence for linkage to the ALDX1 alcoholism phenotype at the ADH3 functional candidate gene was increased in the late onset subgroup (Bonferroni corrected significance level < 0.002), as compared with the unstratified sample that replicated COGA linkage obtained in the same analysis; there was no evidence for linkage at this locus in the early onset subgroup.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Identify and characterize polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 in a Colombian population residing in the city of Bogot� and determine its possible relationship to the alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of a genetic polymorphism of the alcohol-metabolizing enzyme ADH1C with alcohol dependence: results of a case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Despite a number of potential differences between the samples investigated by the prior GWAS and the current study, data presented here provide additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence and extend this finding by demonstrating association with consumption levels in both non-alcoholic and alcohol-dependent populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Numerous SNPs in ADH genes showed association with AD, including one marker in the coding region of ADH1C (rs1693482 in exon6, Ile271Gln).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variations in ADH3 genotypes may account for some of the differences in prevalence of alcohol dependence between genders in the Polish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH3 variation also has significant effects on alcohol dependence, which may be due to linkage to ADH2; the ADH3 effect differs significantly between Asian and European subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It complements an earlier small study and establishes definitively the effects of combinations of the genetic variations of the ADH2 and ADH3 alleles as well as ALDH2, thus providing a precise estimate of the risk for alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of multivariate analyses demonstrated that the odds ratios for an increment of one allele of ADH2*1, ADH3*2 and ALDH2*1 in the development of alcoholism were 4.18, 3.82, and 6.89, respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genotypes and allele frequencies of known polymorphisms in other alcoholism candidate genes, such as alcohol metabolism-related genes [alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 3 (ADH3), and cytochrome P450 2E1 (CYP2E1)] and mu-opioid receptor gene (OPRM1), were studied.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results indicate that acetaldehyde, rather than ethanol or acetate, is primarily responsible for the observed alcohol sensitivity reactions and suggest that substantially lower accumulation of blood acetaldehyde in the heterozygotes significantly re]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The alcoholics had significantly lower frequencies of the ADH2*2, ADH3*1, and ALDH2*2 alleles than did the nonalcoholics, suggesting that genetic variation in both ADH and ALDH, by modulating the rate of metabolism of ethanol and acetaldehyde, influences drinking behavior and the risk of developing alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A new view of alcohol metabolism and alcoholism--role of the high-Km Class III alcohol dehydrogenase (ADH3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Certain genetic variants (i.e., alleles)--particularly the ADH1B*2, ADH1B*3, ADH1C*1, and ALDH2*2 alleles--have been associated with lower rates of alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between ADH1C and ALDH2 polymorphisms and alcoholism in a Turkish sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic association studies of diverse ethnic groups have firmly demonstrated that the allelic variant ADH1B*2 significantly protects against alcoholism but that ADH1C*1, which is in linkage with ADH1B*2, produces a negligible protection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[After the influence of ALDH2*2 was controlled for, multiple logistic regression analysis indicated that allelic variation at ADH3 exerts no significant effect on the risk of alcoholism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A logistic regression extension of the transmission disequilibrium test for continuous traits: application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the Polish population examined, the ADH3*1 allele and the ADH3*1/*1 genotype are conducive to the development of alcoholism, alcohol liver cirrhosis and alcohol chronic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present meta-analysis underscores significant associations of ADH2*1, ADH3*2, and ALDH2*1 alleles and the risk of alcoholism (OR = 1.89 [95% CI 1.56-2.28], 1.32 [95% CI 1.12-1.57], and 4.35 [95% CI 3.04-6.23], respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nine SNPs were located in genes, including the CDH13 and ADH1C genes, that have been reported to be associated with alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genotype for the most active alcohol dehydrogenase enzyme ADH1C was associated with a lower risk of alcoholism (P = .026) and was less prevalent in alcoholics with DRD2TaqIA2/A2 (P = .047), GABAA-beta2 1412C/C (P = .01), or EAAT2 603G/A (P = .022) genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For subjects with ALDH2*1/*1 and at least one ADH2*2 allele, the genotype of ADH3 was not associated with self-reported flushing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The study does not indicate an important role for the ADH3 (*)1 polymorphism in SCCHN, but larger numbers are needed to more precisely estimate the interaction, if any, with ADH3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A methylated upstream region of ADH1C achieved histone H3 hyperacetylation upon either 5-aza-dC or TSA treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The proximal ADH4 promoter functioned in a hepatoma cell line (H4IIE-C3) and a kidney cell line (CV-1).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Logistic regression analysis of genotypes obtained via Illumina GoldenGate and Sequenom iPlex technologies revealed the following age- and study-adjusted associations: EPHX1 rs1051740 with increased serous ovarian cancer risk [per-allele odds ratio (OR) 1.17, 95% confidence interval (95% CI) 1.04-1.32, P?=?0.01), ADH4 r1042364 with decreased ovarian cancer risk (OR 0.90, 95% CI: 0.81-1.00, P?=?0.05), and NQO1 rs291766 with increased ovarian cancer risk (OR 1.11, 95% CI: 1.00-1.23, P?=?0.04).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequency of ADH 2(2) allele was significantly higher in the chronic alcoholic pancreatitis group, compared with alcoholics with normal pancreatic function; but, it was not significantly different from that in the chronic nonalcoholic pancreatitis group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This suggests a role for genetic variations of ADH4 as risk factors for the development of PD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[an association between a certain ADH4 (formerly known as ADH7 in humans) allele and PD. This suggests a role for genetic variations of ADH4 as risk factors for the development of PD. Our data also show that the observed polymorphisms alone are not suffici]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.